p75NTR MEDIATES EPHRIN-A REVERSE SIGNALING
AssigneeThe Salk Institute for Biological Studies
InventorsDennis D.M. O'Leary, Yoo-Shick Lim, Todd McLaughlin
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Abstract
The disclosure comprises methods and compositions for stimulating axon outgrowth and inhibiting metastatic diseases and disorders.
Claims20
A method of treating a neurological disease, disorder or injury, comprising:
- contacting a nerve location with an antagonist agent of p75NTR.
A method of treating a neurological disease, disorder or injury, comprising:
- contacting a nerve location with an agent that inhibits the interaction of p75NTR with an ephrin A.
A method of stimulating axonal outgrowth comprising contacting a nerve with an agent that inhibits the interaction of P75NTR with an ephrin A.
A method of stimulating axonal outgrowth comprising contacting a nerve with an agent that antagonizes p75NTR activity.
A method of treating mono or polyneuropathy comprising contacting a subject with an agent that inhibits the interaction of p75NTR with an ephrin A or an antagonist of ephrinA-p75NTR complex activity.
A method of treating metastasis comprising contacting a subject with a metastatic disorder or disease with an agent that promotes the interaction of p75NTR and ephrin A or with an agonist of p75-ephrin A complex activity.
A method of screening an agent that is useful for inducing axon outgrowth or cell motility comprising contacting a cell with the agent and measuring (i) the phosphorylation of Fyn or (ii) the interaction of p75NTR and ephrin A, wherein an agent the promotes phosphorylation of Fyn or the interaction of P75NTR and ephrin A is an agent useful for simulating axon outgrowth.
Dependencies are inferred from the claim text.