Modified soluble fgf receptor fc fusions wsith improved biological activity
AssigneeCentelion
InventorsFrancis Blanche, Beatrice Cameron, Mark Nesbit, Sylvie Sordello, Celine Nicolazzi, Marc Trombe
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Abstract
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.
Claims39
A modified soluble FGF receptor Fc fusion comprising a fusion of a soluble fragment or domain of a FGF receptor with an Fc region of an immunoglobulin, wherein at least the 5th N-glycosylation site of the FGF receptor moiety is occupied, and at most 45% of the N-glycans of said FGF receptor moiety have no sialyl group.
Dependencies are inferred from the claim text.