Back to results
US 2010/0061966 A1Published application
Cardiac Stem Cells
AssigneeThe Johns Hopkins University
InventorsEduardo Marban, Maria Roselle Abraham, Rachel R. Smith
Life of this patent
Estimating the term…
Abstract
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.
Claims16
A method of increasing the amount of viable cardiac tissue in a mammal having diseased or damaged cardiac tissue comprising:
- harvesting mammalian cardiac tissue;
- processing said cardiac tissue to yield cardiospheres;
- culturing said cardiospheres on a solid substrate to generate cardiosphere-derived cells;
- identifying a mammal have both viable and damaged cardiac tissue;
- and
- administering a therapeutically effective amount of said cardiosphere-derived cells to the heart of said mammal, wherein after administration, said cardiosphere-derived cells engraft into said diseased or damaged heart tissue to generate additional viable cardiac tissue thereby increasing the amount of viable cardiac tissue in said mammal.
3 more elements
Dependencies are inferred from the claim text.