Amido Anti-Viral Compounds, Compositions, And Methods Of Use

A compound that is Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:

• one of E or F is —N═ and the other of E or F is —O—, —S—, or —NH—;
• each R1 is independently selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminocarbonyl, aryl, substituted aryl, carboxyl, carboxyl ester, cycloalkyl, substituted cycloalkyl, halo, hydroxy, heteroaryl, substituted heteroaryl, heterocyclic, substituted heterocyclic, nitro, thiol, alkylthio, substituted sulfonyl, aminosulfonyl, and substituted alkylthio;
• m is 1 or 2;
• T is C2-C6 alkylene wherein optionally one —CH2-group is replaced with —NRk—, —S—, —SO—, —SO2—, or —O—, and Rk is selected from the group consisting of hydrogen, acyl, aminocarbonyl, alkyl, substituted alkyl, substituted sulfonyl, and carboxyl ester;
• Y1 is attached to a carbon atom on T and is independently selected from the group consisting of halo, oxo, hydroxy, and alkoxy;
• p is 0, 1, or 2;
• Ra and Rb are independently selected from the group consisting of hydrogen, cyano, haloalkyl, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic;
• Rc is selected from the group consisting of hydrogen, alkyl, and substituted alkyl;
• and
• Rd is selected from the group consisting of hydrogen, alkyl, substituted alkyl, acyl, an amino acid residue attached via a peptide bond, aminocarbonyl, substituted aminocarbonyl, substituted sulfonyl, aminosulfonyl, carboxyl ester, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and heterocyclic.