System and method for determining amount of radioactive material to administer to a patient

A computerized method for determining an optimum amount of radioactivity to administer to a patient, comprising:

• obtaining at least one image relating to anatomy of a particular patient;
• obtaining multiple images regarding radioactivity distribution over time in the particular patient;
• registering the images related to the radioactivity distribution over time;
• combining each radioactivity image with each anatomy image to create an activity image;
• running a Monte Carlo simulation for each activity image to obtain a dose image at multiple times;
• using the dose image at each time to obtain a dose-rate image and a total dose image;
• using the dose-rate image and total dose image to obtain a BED image;
• using the BED image to obtain an EUD of BED values for a chosen anatomical region.

The method of 11, wherein the particular total dose image is depicted as:

• a differential BED histogram;
• an integral BED histogram;
• or
• iso BED contours over the image;
• or
• any combination thereof.

A computerized method for determining an optimum amount of radioactivity to administer to a patient, comprising:

• obtaining at least one image relating to anatomy of a particular patient;
• obtaining multiple images regarding radioactivity distribution over time in the particular patient;
• registering the images related to the radioactivity distribution over time;
• integrating the radioactivity images across time voxel-wise to obtain a cumulated activity image;
• combining the cumulative activity image with the anatomy image to establish a corresponding set of images representing the cumulated activity in each voxel and the corresponding density and composition for the voxel;
• running a Monte Carlo simulation for each set of images to obtain a total dose image;
• and
• using the total dose image to obtain the EUD of dose value for a user-defined region.

A computerized system for determining an optimum amount of radioactivity to administer to a patient, comprising:

• a server coupled to a network;
• a user terminal coupled to the network;
• an application coupled to the server and/or the user terminal, wherein the application is configured for:
• assuming an activity retention limit;
• utilizing the activity retention limit to determine a dose rate for a phantom category;
• utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category;
• and
• utilizing the dose rate for a second phantom category to find information regarding the second phantom category.

A computerized system for determining an optimum amount of radioactivity to administer to a patient, comprising:

• a server coupled to a network;
• a user terminal coupled to the network;
• an application coupled to the server and/or the user terminal, wherein the application is configured for:
• obtaining at least one image relating to anatomy of a particular patient;
• obtaining multiple images regarding radioactivity distribution over time in the particular patient;
• registering the images related to the radioactivity distribution over time;
• combining each radioactivity image with each anatomy image to create an activity image;
• running a Monte Carlo simulation for each activity image to obtain a dose image at multiple times;
• using the dose image at each time to obtain a dose-rate image and a total dose image;
• using the dose-rate image and total dose image to obtain a BED image;
• using the BED image to obtain an EUD of BED values for a chosen anatomical region.

A computerized system for determining an optimum amount of radioactivity to administer to a patient, comprising:

• a server coupled to a network;
• a user terminal coupled to the network;
• an application coupled to the server and/or the user terminal, wherein the application is configured for:
• obtaining at least one image relating to anatomy of a particular patient;
• obtaining multiple images regarding radioactivity distribution over time in the particular patient;
• registering the images related to the radioactivity distribution over time;
• integrating the radioactivity images across time voxel-wise to obtain a cumulated activity image;
• combining the cumulative activity image with the anatomy image to establish a corresponding set of images representing the cumulated activity in each voxel and the corresponding density and composition for the voxel;
• running a Monte Carlo simulation for each set of images to obtain a total dose image;
• and
• using the total dose image to obtain the EUD of dose value for a user-defined region.