Flow schemes for enhanced light-target interaction in fluidic channels
AssigneePalo Alto Research Center Incorporated
InventorsMarkus Beck, Peter Kiesel, Michael Bassler, Tobias Burgel
Life of this patent
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Abstract
An embodiment is a fluidic channel to enhance light-target interaction. A first channel portion receives a first excitation light, an analyte flow, and a sheath flow. The analyte flow and the first excitation light are separated while in the first channel portion. The sheath flow flows on two sides or surrounds the analyte flow. A second channel portion has a first redirection structure to redirect the analyte flow by the sheath flow into the first excitation light at a first detection area.
Claims25
An apparatus comprising:
- a first channel portion receiving a first excitation light, an analyte flow, and a sheath flow, the analyte flow and the first excitation light being separated while in the first channel portion, the sheath flow flowing on two sides or surrounding the analyte flow;
- and
- a second channel portion having a first redirection structure coupled to the first channel portion to redirect the analyte flow by the sheath flow into the first excitation light at a first detection area.
A method comprising:
- receiving a first excitation light, an analyte flow, and a sheath flow to go through a first channel portion, the analyte flow and the first excitation light being separated while in the first channel portion, the sheath flow flowing on two sides or surrounding the analyte flow;
- and
- redirecting the analyte flow by the sheath flow into the first excitation light at a first detection area using a first redirection structure of a second channel portion.
A system comprising:
- an optical unit to generate at least a light beam of excitation light;
- and
- a flow delivery unit to deliver a sheath flow and an analyte flow;
- and
- a fluidic channel coupled to the flow delivery and optically coupled to the optical unit, the fluidic channel comprising:
- a first channel portion receiving a first excitation light of the at least light beam, the analyte flow, and the sheath flow, the analyte flow and the first excitation light being separated while in the first channel portion, the sheath flow flowing on two sides or surrounding the analyte flow, and
- a second channel portion having a first redirection structure coupled to the first channel portion to redirect the analyte flow by the sheath flow into the first excitation light at a first detection area.
An apparatus comprising:
- a first channel portion receiving a first excitation light, an analyte flow, and a sheath flow, the analyte flow and the first excitation light being aligned while in the first channel portion in an area, the sheath flow flowing on two sides or surrounding the analyte flow;
- and
- a second channel portion having a first redirection structure coupled to the first channel portion to redirect the analyte flow by the sheath flow out of the first excitation light away from the area.
Dependencies are inferred from the claim text.