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US 2010/0059674 A1Published application
Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (ls-desi-ms)
AssigneeOhio University
InventorsHao Chen, Zhixin Miao
Life of this patent
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Abstract
An apparatus and method for direct analysis of continuous-flow liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS) including a sample stage that is adapted to receive a liquid sample and a nebulizing ionizer that is configured to generate a charged, nebulized solvent and thereby desorb at least a portion of the liquid sample from the sample stage.
Claims26
A liquid sample ionizer comprising:
- a sample stage adapted to receive a liquid sample;
- and
- a nebulizing ionizer configured to generate a charged, nebulized solvent and direct the nebulized solvent onto the liquid sample on the sample stage to thereby desorb at least a portion of the liquid sample from the sample stage.
A mass spectrometer comprising:
- an ion source comprising a sample stage adapted to receive a liquid sample and a nebulizing ionizer configured to generate a charged, nebulized solvent and thereby desorb and ionize at least a portion of the liquid sample from the sample stage as an ionized sample;
- a mass analyzer connected to the ion source and configured to analyze a mass-to-charge ratio of the ionized sample;
- and
- a controller configured to operate the ion source or the mass analyzer, or a combination thereof.
1 more element
A method of ionizing a liquid sample for mass spectroscopy analysis comprising:
- generating a charged, nebulized solvent;
- directing the charged, nebulized solvent to a liquid sample thereby desorbing and ionizing at least a portion of the liquid sample to form an ionized liquid sample;
- and
- directing the ionized liquid sample to a mass analyzer.
1 more element
A method of analyzing a liquid sample comprising:
- introducing a liquid sample to a sample stage;
- generating a charged, nebulized solvent;
- directing the charged, nebulized solvent to the liquid sample on the sample stage thereby desorbing and ionizing at least a portion of the liquid sample as an ionized sample from the sample stage and directing the ionized sample in a direction substantially toward a mass analyzer;
- separating an ionized solvent from the ionized sample;
- and
- analyzing a mass-to-charge ratio of the ionized sample.
3 more elements
Dependencies are inferred from the claim text.