Novel Isolated And Purified Strains Of Chikungunya Virus And Polynucleotides And Polypetide Sequences, Diagnostic And Immunogenical Uses Thereof
OwnerPhilippe Despres, Anne-Claire Brehin +3inventors
InventorsPhilippe Despres, Anne-Claire Brehin, Valerie Marechal, Pierre Charneau, Philippe Souque
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Abstract
The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
Claims49
An isolated and purified wild strain of chikungunya virus (CHIKV) capable of in vitro infecting human cells.
An isolated and purified strain of chikungunya virus (CHIKV) comprising at least one mutation in structural protein E1 and/or structural protein E2.
An isolated and purified polynucleotide comprising all or part of the sequence as shown in FIG. 4, 5, 6, 7, 8 or 9 (SEQ ID NOS 1, 2, 3, 4, 5 or 6).
A purified polypeptide comprising all or part of the sequence as defined in FIGS. 38 to 49 (SEQ ID NOS:
- 24 to 34 and 78)
A purified polypeptide comprising all or part of the sequence as defined in FIG. 18, 19, 20 or 21 (SEQ ID NOS 15, 16, 17, or 18).
A purified polypeptide comprising all or part of the sequence as defined in FIG. 22, 23, 24 or 25 (SEQ ID NOS 19, 20, 21, or 22).
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