Phenobarbital salts; methods of making; and methods of use thereof

Amorphous phenobarbital sodium salt or a corresponding anhydrous form, hydrate, or solvate thereof

A method of preparing a crystalline salt of phenobarbital, comprising:

• crystallizing or precipitating a phenobarbital salt from a solution of phenobarbital, a counterion source, and a solvent;
• wherein the crystalline salt of phenobarbital is selected from the group consisting of phenobarbital potassium, phenobarbital benzathine, phenobarbital betaine, and corresponding anhydrous forms, hydrates, solvates, or polymorphic forms thereof.

A composition comprising:

• a compound which is a crystalline salt of phenobarbital selected from the group consisting of phenobarbital potassium, phenobarbital benzathine, phenobarbital betaine, and corresponding anhydrous forms, hydrates, solvates, or polymorphic forms thereof;
• and
• a pharmaceutically acceptable excipient.