System and Method for Pseudo-Continuous Measurement of Metabolite Concentrations in a Mammalian Body
AssigneeG-Sense Ltd.
InventorsAvraham Shekalim, Noam Peleg
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Abstract
A metabolite monitoring system comprising a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet, a fluid delivery device for delivering dialysate to said inlet; and a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.
Claims19
A metabolite monitoring system comprising:
- (a) a microdialysis probe including a semi-permeable membrane and a probe flow path passing from an inlet through a sensing volume adjacent to said semi-permeable membrane to an outlet;
- (b) a fluid delivery device for delivering dialysate to said inlet;
- and
- (c) a metabolite monitoring system associated with said outlet for monitoring a concentration of at least one metabolite in said dialysate from said microdialysis probe, wherein said fluid delivery device is configured to deliver a pulsed flow of said dialysate to said inlet.
A metabolite monitoring system comprising:
- (a) a microdialysis probe;
- (b) a dialysate delivery arrangement for generating flow of a dialysate into and out from said microdialysis probe;
- and
- (c) a reagent delivery arrangement for supplying a reagent for mixing with the dialysate from said microdialysis probe, wherein said reagent delivery arrangement and said dialysate delivery arrangement each includes a fluid reservoir acted upon by a piston to deliver the fluid, wherein said reagent delivery arrangement and said dialysate delivery arrangement are mechanically linked so as to maintain a fixed ratio between a quantity of dialysate delivered and a quantity of reagent delivered.
19-26. (canceled)
Dependencies are inferred from the claim text.