Beta-lactamase inhibitory compounds

A compound of Formula (I):

• wherein p is 0, 1, or 2;
• R1 and R2 each independently comprises H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl, wherein any alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl can be independently substituted with 0-3 J;
• J is R′ except H, haloalkyl, (CH2)n—OR′, (CH2)n—OC(O)N(R′)2, (CH2)n—CN, CF3, OCF3, O, S, C(O), S(O), methylenedioxy, ethylenedioxy, (CH2)n—N(R′)2, (CH2)n—SR′, (CH2)n—S(O)R′, (CH2)n—S(O)2R′, (CH2)n—S(O)2N(R′)2, (CH2)n—SO3R′, (CH2)n—C(O)R′, (CH2)n—C(O)C(O)R′, (CH2)n—C(O)CH2C(O)R′, (CH2)n—C(S)R′, (CH2)n—C(O)OR′, (CH2)n—OC(O)R′, (CH2)n—C(O)N(R′)2, (CH2)n—OC(O)N(R′)2, (CH2)n—C(S)N(R′)29 (CH2)n—NHC(O)R′, (CH2)n—N(R′)N(R′)C(O)R′, (CH2)n—N(R′)N(R′)C(O)OR′, (CH2)n—N(R′)N(R′)CON(R′)2, (CH2)n—N(R′)SO2R′, (CH2)n—N(R′)SO2N(R′)2, (CH2)n—N(R′)C(O)OR′, (CH2)n—N(R′)C(O)R′, (CH2)n—N(R′)C(S)R′, (CH2)n—N(R′)C(O)N(R′)2, (CH2)n—N(R′)C(S)N(R′)2, (CH2)n—N(R′)C(═NR)N(R′)2, (CH2)n—C(═NR)N(R′)2, (CH2)n—N(COR′)COR′, (CH2)n—N(OR′)R′, (CH2)n—C(═NH)N(R′)2, (CH2)n—C(O)N(OR′)R′, (CH2)n—N(R′)C(═NR′)N(R′)2 or (CH2)n—C(═NOR′)R′, wherein n is 0 to about 4, and wherein;
• each R′ is independently at each occurrence hydrogen, (C1-C12)-alkyl, (C3-C10)-cycloalkyl or (C3-C10)-cycloalkenyl, [(C3-C10)cycloalkyl or (C3-C10)-cycloalkenyl]-(C1-C12)-alkyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C12)-alkyl, (C3-C10)-heterocyclyl, (C3-C10)-heterocyclyl-(C1-C12)-alkyl, (C5-C10)-heteroaryl, or (C5-C10)-heteroaryl-(C1-C12)-alkyl, wherein any alkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl is substituted with 0-3 substituents selected independently from J;
• or, two R′ groups together with a nitrogen atom to which both R′ groups are attached or with two adjacent nitrogen atoms to which each R′ group is respectively attached form a mono- or bicyclic ring system;
• R3 comprises hydrogen, OH, OC(O)R″, OC(O)OR″, OC(O)NHR″, NHC(O)R″, NHC(O)NHR″, or NHC(═NH)NHR″, where R″ is H, (C1-C12)alkyl, aryl, heteroaryl, or (CH2)nNHR′″, wherein n=2, 3, or 4 and R′″═H, C(═NH)NH2, C(═NH)H, or R3 comprises (C1-C12)-alkyl, (C3-C10)-cycloalkyl or (C3-C10)-cycloalkenyl, [(C3-C10)cycloalkyl or (C3-C10)-cycloalkenyl]-(C1-C12)-alkyl, (C6-C10)-aryl, (C6-C10)-aryl-(C1-C12)-alkyl, (C3-C10)-heterocyclyl, (C3-C10)-heterocyclyl-(C1-C12)-alkyl, (C5-C10)-heteroaryl, or (C5-C10)-heteroaryl-(C1-C12)-alkyl, wherein R″ is substituted with 0-3 substituents selected independently from J;
• and,
• R4 is H, a (C1-C6)alkyl or aryl group, or a pharmaceutically acceptable cation;
• or,
• a compound of Formula (II):
• wherein n, p, R1, R2, R4, R′, and J are as defined above, and
• R5 comprises H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl, wherein any alkyl, aryl, cycloalkyl, cycloalkylalkyl, heterocyclyl, or heteroaryl can be independently substituted with 0-3 J;
• or a salt, zwitterion, pharmaceutically acceptable salt, hydrate, solvent, tautomer, stereoisomer, or prodrug thereof.