CpG DNA Adjuvant in Avian Vaccines
AssigneeNational Pingtung University of Science and Technology
InventorsHso-Chi Chaung, Li-Hsiang Hung, Yi-Yang Lien
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Abstract
A CpG DNA adjuvant in avian vaccines is disclosed, which includes an immunostimulatory oligodeoxynucleotide (ODN) having a plurality of TCG tandem repeats at a 5′end, a poly-G structure at a 3′ end, and at least one unmethylated CpG motif with avian specific flanking sequences at two ends thereof between the 5′ end and the 3′ end. The CpG DNA adjuvant in avian vaccines is advantageous to carry out large-scale production, specifically enhance avian innate and adaptive immune responses, and the CpG DNA adjuvant is hardly to be digested by DNase due to its particular structures.
Claims6
A CpG DNA adjuvant in avian vaccines, the CpG DNA adjuvant in avian vaccines has an immunostimulatory oligodeoxynucleotide (ODN) having a sequence including the following formula:
- 5′TrBbPg3′
- wherein Tr denotes a plurality of TCG tandem repeats at a 5′ end of the immunostimulatory ODN, Pg denotes a poly-G structure essentially consisted of 4 to 6 guanines at a 3′ end of the immunostimulatory ODN, and Bb denotes at least one unmethylated CpG motif with avian specific flanking sequences at two ends of the CpG motif between the 5′ end and the 3′ end of the immunostimulatory ODN.
Dependencies are inferred from the claim text.