Reduction of Zinc-Induced Neurotoxic Injury By Blockade of Nitric Oxide Synthesis
AssigneeAndro Diagnostics
InventorChristopher J. Frederickson
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Abstract
The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.
Claims13
A method for treating a subject with a clinical condition associated with zinc-mediated neurotoxic injury, said method comprising administering to the subject in need of such a treatment a therapeutically effective amount of a compound that reduces the amount of zinc release from the neurons.
A method for preventing a clinical condition associated with zinc-mediated neurotoxic injury, said method comprising administering to an individual susceptible to trauma-induced excitotoxicity a compound that reduces the amount of zinc release from neuronal cells in response to the trauma-induced excitotoxicity, thereby preventing the clinical condition associated with zinc-mediated neurotoxic injury.
Dependencies are inferred from the claim text.