Long-acting polypeptides and methods of producing same
AssigneeModigene Inc
InventorsFuad FARES, Udi Eyal Fima
Life of this patent
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Abstract
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
Claims24
A polypeptide comprising a cytokine, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to an amino terminus of said cytokine, and two chorionic gonadotrophin carboxy terminal peptides attached to a carboxy terminus of said cytokine.
A polynucleotide comprising a coding portion encoding a polypeptide, said polypeptide comprises a cytokine, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to an amino terminus of said cytokine, and two chorionic gonadotrophin carboxy terminal peptides attached to a carboxy terminus of said cytokine.
A method of extending a biological half life of a cytokine, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said cytokine and two chorionic gonadotrophin carboxy terminal peptides to a carboxy terminus of said cytokine, thereby improving a biological half life of a cytokine.
A method of improving the area under the curve (AUC) of a cytokine, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said cytokine and two chorionic gonadotrophin carboxy terminal peptides to a carboxy terminus of said cytokine, thereby improving the area under the curve (AUC) of a cytokine.
A method of reducing a dosing frequency of a cytokine, comprising the step of attaching one chorionic gonadotrophin carboxy terminal peptide to an amino terminus of said cytokine and two chorionic gonadotrophin carboxy terminal peptides to a carboxy terminus of said cytokine, thereby reducing a dosing frequency of a cytokine.
A method of increasing compliance in the use of cytokine therapy, comprising providing to a subject in need thereof, a polypeptide comprising a cytokine, one chorionic gonadotrophin carboxy terminal peptide (CTP) attached to an amino terminus of said cytokine, and two chorionic gonadotrophin carboxy terminal peptides attached to a carboxy terminus of said cytokine, thereby increasing compliance in the use of cytokine therapy.
Dependencies are inferred from the claim text.