Cell penetrating peptides for intracellular delivery of molecules
AssigneesCentre National De La Recherche Scientifique, Panomics, Inc.
InventorsGilles Divita, Frederic Heitz, May Catherine Morris, Gudrun Aldrian-Herrada
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Abstract
The present invention concerns cell-penetrating peptides which comprise an amino acid sequence consisting of GLX9RALX9RX1LX2RSLX9X3X4X5X6X7X8 (SEQ ID No: 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, and X8 is A, V or Q, and X9 is W, F or Y. These CPPs can be used as vectors for delivering nucleic acids and/or proteins and/or peptides to cells, in vitro or in vivo.
Claims23
A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of GLX9RALX9RX1 LX2RSLX9X3X4X5X6X7X8 (SEQ ID No:
- 1), wherein X1 is A, L or G, X2 is W or none, X3 is R or K, X4 is K, L or S, X5 is L or K, X6 is R or W, X7 is K or S, X8 is A, V or Q, and X9 is W, F or Y.
Dependencies are inferred from the claim text.