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AssigneeOscient Pharmaceuticals Corporation
InventorsTIM KEITH, Randall D. Little, Paul Van Eerdewegh, Josee Dupuis, Richard G. Del Mastro, Jason Simon, Kristina Allen, Sunil Pandit
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This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
An isolated nucleic acid encoding a polypeptide comprising at least 7 contiguous amino acids of the sequence set forth in SEQ ID NO:
An isolated nucleic acid comprising at least 15 contiguous nucleotides from the nucleotide sequence of SEQ ID NO:
An isolated nucleic acid comprising a nucleotide sequence which is 90% identical to the nucleotide sequence set forth in SEQ ID NO:
An isolated nucleic acid gene 561 probe comprising at least 8 contiguous nucleotides of a nucleotide sequence set forth in a member selected from the group consisting of Table 8, Table 9, Table 11A and Table 11B.
Dependencies are inferred from the claim text.