Eponemycin and epoxomicin analogs and uses thereof

A compound having the structure (I):

• and pharmaceutically acceptable derivatives thereof;
• wherein each occurrence of E or D is independently absent, CRA, CRARB, C═O, O, S, NRA, or N, wherein each occurrence of RA and RB is independently hydrogen, a protecting group, or an aliphatic, alicyclic, heteroaliphatic heteroalicyclic, aryl or heteroaryl moiety;
• D and E are linked by a single or double bond as valency permits;
• z is 0, 1, 2, 3, 4, 5 or 6;
• R1, R2, R3 and R4 are each independently hydrogen, halogen, —CN, —ORC, —SRC, —NRCRD, —(C═O)RC or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, wherein each occurrence of RC and RD is independently hydrogen, a protecting group, or an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety, or RC and RD, taken together, form a heteroalicyclic or heteroaryl moiety;
• or wherein any two adjacent groups R1, R2, R3 and R4, taken together, form an alicyclic or heteroalicyclic moiety, or an aryl or heteroaryl moiety;
• R5 and R6 are each independently an aliphatic, alicyclic, heteroaliphatic, heteroalicyclic, aryl or heteroaryl moiety;
• and Q is an epoxycarbonyl moiety having the structure:
• wherein RQ1 is hydrogen an aliphatic, alicyclic heteroaliphatic, heteroalicyclic aryl or heteroaryl moiety, an oxygen protecting group or a prodrug moiety.