Substituted indazole derivatives, their manufacture and use as pharmaceutical agents

A compound according to formula I,

• wherein
• R1 is alkyl;
• R2 and R3 are alkyl;
• one of R4 and R5 is selected from the group consisting of:
• a) -X-heteroaryl, wherein the heteroaryl is optionally substituted one to three times by alkyl, alkyl-C(O)—, alkoxy, fluorinated alkyl, fluorinated alkoxy, cyano, nitro, amino, alkylamino, dialkylamino or halogen;
• b) -Y-phenyl, wherein the phenyl is:
• (i) optionally substituted one to three times by alkyl, alkyl-C(O)—, carboxy, alkyl-NHC(O)—, alkoxy, fluorinated alkyl, fluorinated alkoxy, cyano, hydroxy, nitro, amino, alkylamino, dialkylamino, alkyl-C(O)NH—, alkyl-S(O)2NH—, halogen, 2,4-dioxa-pentan-1,5-diyl or 2,5-dioxa-hexan-1,6-diyl;
• or
• (ii) substituted once by phenyl;
• and
• c) -Z-cycloalkyl;
• and the other of R4 and R5 is hydrogen;
• X is a single bond or —C≡C—;
• Y is selected from the group consisting of:
• a single bond, —CH═CH— and —C≡C—;
• Z is —CH═CH—;
• or a pharmaceutically acceptable salt thereof.