Proteins for use in diagnosing and treating infection and disease
OwnerMichael Agadjanyan, Haig Keledjianinventors
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Abstract
The present invention describes a composition comprised on cystatin A and at least one histone used in diagnostic tools and for the treatment of diseases associated with reduced T helper cell counts such as HIV-1 infection, AIDS, ARC, multiple sclerosis, chronic fatigue syndrome, heumatoid arthritis, Alzheimer's disease, dermatitis, type 1 diabetes mellitus, colitis, inflammatory bowel disease / irritable bowel syndrome, Crohn's disease, Psoriasis, Chronic obstructive pulmonary disease, System lupus erythematosus, transplant rejection and cancer.
Claims39
A composition comprising
- (a) a cystatin A protein;
- and
- (b) at least one histone protein,
- wherein said composition is free of other thymus proteins and suitable for administration to humans, optionally with a pharmaceutically acceptable adjuvant or carrier.
A composition comprising
- (a) a cystatin A protein;
- and
- (b) at least one histone protein,
- wherein said composition is free of other thymus proteins and suitable for administration to humans, and at least one of said cystatin A protein and said at least one histone protein is complexed to at least one member selected from the group consisting of CD4, gp120 and gp41, optionally with a pharmaceutically acceptable adjuvant and/or carrier.
A method of treatment for AIDS (HIV-1 infection) or individuals at risk of acquiring AIDS comprising administering to a subject in need thereof a composition comprising
- (a) a cystatin A protein;
- and
- (b) at least one histone protein,
- wherein said composition is free of other thymus proteins and suitable for administration to humans, optionally with a pharmaceutically acceptable adjuvant or carrier.
A method of treatment for AIDS (HIV-1 infection) or individuals at risk of acquiring AIDS comprising administering to a subject in need thereof a composition to humans comprising
- (a) a cystatin A protein;
- and
- (b) at least one histone protein,
- wherein said composition is free of other thymus proteins and suitable for administration to humans, and at least one of said cystatin A protein and said at least one histone protein is complexed to at least one member selected from the group consisting of CD4, gp120 and gp41, optionally with a pharmaceutically acceptable adjuvant and/or carrier.
A method for diagnosing HIV-1 infection (AIDS) comprising
- (a) collecting a blood, serum or plasma sample from a subject;
- (b) mixing said sample with a composition comprising
- (i) a cystatin A protein;
- and
- (ii) at least one histone protein;
- and
- (c) identifying a complex of said composition bound to any one of CD4, gp120 and gp41,
- wherein said complex is indicative of HIV-1 infection.
A kit for detection of HIV infection comprising comprising
- (a) a cystatin A protein;
- (b) at least one histone protein;
- and
- (c) a device for identifying at least one complex of said cystatin A protein and said at least one histone protein with CD4, gp120 or gp41.
A method of treatment for disease associated with a decrease in the number of TH cells comprising administering to a subject in need thereof a composition comprising
- (a) a cystatin A protein;
- and
- (b) at least one histone protein,
- wherein said composition is free of other thymus proteins and suitable for administration to humans, optionally with a pharmaceutically acceptable adjuvant or carrier.
Dependencies are inferred from the claim text.