Method of Calibrating an Analyte-Measurement Device, and Associated Methods, Devices and Systems

An in vivo analyte sensor calibration system, comprising:

• an in vivo analyte sensor, at least a portion of the sensor subcutaneously positioned to generate one or more signals;
• a transmission element operatively coupled to the in vivo analyte sensor and configured to transmit one or more analyte-related signals of the in vivo analyte sensor;
• a calibration sensor configured to be placed in contact with a blood sample from an off-finger calibration site to provide a calibration measurement;
• and
• a data processing element configured to physically couple with the calibration sensor to communicate with the transmission element, the data processing element further configured to determine a quality of the calibration measurement and a quality of the one or more generated signals from the in vivo analyte sensor, and to convert the one or more generated signals from the in vivo analyte sensor into a corresponding one or more analyte concentration level based on the calibration measurement if the quality of the calibration measurement and the quality of the one or more generated signals from the in vivo analyte sensor are suitable for calibration.