Method and apparatus of low strengh electric field network-mediated delnery of drug, gene, sirna, shrn, protein, peptide, antibody or other biomedical and therapeutic molecules and reagents in skin, soft tissue, joints and bone
AssigneeThe Regents of the University of California
InventorLuyi Sen
Life of this patent
Estimating the term…
Abstract
The illustrated embodiments of the invention include four preferred embodiments: 1) a method and apparatus for the joint and its related soft tissue for bone gene, protein and drug delivery; 2) a method and apparatus for gene, protein and drug delivery to an extremity; 3) a method and apparatus for delivery of gene, protein and drug delivery to skin and soft tissue; and/or 4) a method and apparatus for delivery of a gene, protein and drug to soft tissue tumor.
Claims29
A method of transfecting a drug, gene, siRNA, shRNA, peptide, protein, antibody or a biomedical therapeutic molecule or reagent into tissue in a joint, bone, soft tissue related to the joint or bone, or into soft tissue in general comprising the steps of:
- distributing the drug, gene, siRNA, shRNA, peptide, protein, antibody or a biomedical therapeutic molecule or reagent throughout the tissue;
- disposing at least one positive electrode into or onto the tissue;
- disposing an array of negative electrodes in proximity to the whole of the tissue to be transfected;
- and
- applying a pulsed, low strength, network electrical field (LSEN) to whole of the tissue to be transfected.
An apparatus for transfecting a drug, gene, siRNA, shRNA, peptide, protein, antibody or a biomedical therapeutic molecule or reagent into tissue in a joint, bone, soft tissue related to the joint or bone, or into soft tissue in general comprising:
- means for distributing the drug, gene, siRNA, shRNA, peptide, protein, antibody or a biomedical therapeutic molecule or reagent throughout the tissue;
- at least one positive electrode inserted into or disposed on the tissue;
- an array of negative electrodes disposed in proximity to the whole of the tissue to be transfected;
- and
- a pulsed, low strength, network electrical field (LSEN) generator to apply LSEN to whole of the tissue to be transfected.
Dependencies are inferred from the claim text.