Biliary/Pancreatic Shunt Device and Method for Treatment of Metabolic and Other Diseases
AssigneeSatiogen Pharmaceuticals, Inc.
InventorAndrew Young
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Abstract
Provided is a shunt device that promotes stimulation of secretion of intestinal L-cells and other enteroendocrine cell types. Enteroendocrine secretion is stimulated directly or indirectly by shunting bile and/or pancreatic secretion to segments of the gut more distal than would normally occur The shunt device may be a flexible catheter that is impervious to such secretions, with a proximal end draining the pancreatic/bile duct, and a distal end residing distally within the lumen of the small or large intestine. The shunt may be inserted with minimally invasive techniques, such as by endoscopy.
Claims42
A shunt device comprising a catheter that facilitates transfer of at least one endogenous secretion from the biliary/pancreatic tree of an animal to at least one distal entry location of the gut that is further along the digestive tract than the anatomical entry location of the endogenous secretion into the digestive tract each distal entry location including enteroendocrine cells lining the gut.
A shunt device comprising a conduit that facilitates transfer of at least one endogenous secretion from the biliary/pancreatic tree of an animal to at least one distal entry location of the gut that is further along the digestive tract than an anatomical entry location of the endogenous secretion into the digestive tract, the shunt device isolating the at least one endogenous secretion from enteroendocrine cells lining the gut until the endogenous secretion reaches the distal entry location, the shunt device being endoscopically insertable into a human.
A method for enhancing secretion of gut peptides from enteroendocrine cells lining the gut in an animal, comprising:
- directing bile from at least one of the gall bladder and the hepatic duct to at least one distal location further down the digestive tract than the anatomical entry point of the bile into the digestive tract via a catheter, thereby enhancing secretion of gut peptides from enteroendocrine cells lining the gut in the animal.
A method for producing weight loss in an animal, comprising:
- preventing at least one endogenous secretion from the biliary/pancreatic tree from contacting cell linings in the gut of an animal until the least one endogenous secretion reaches at least one distal location further down the digestive tract than the anatomical entry point of the least one endogenous secretion into the digestive tract, thereby enhancing secretion of gut peptides from enteroendocrine cells lining the gut in the animal, slowing emptying of the stomach and effecting weight loss in the animal.
Dependencies are inferred from the claim text.