Biology guided adaptive therapy planning
AssigneeKoninklijke Philips Electronics N. V.
InventorsAlexander Fischer, Lothar Spies
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Abstract
A therapy system (100) includes an imager (102), a therapy planner (104), and a therapy device (106). The therapy planner (104) includes a therapy prescription apparatus (118) which calculates a desired therapy (D) to be applied to a human patient or other subject. The therapy prescription system (118) uses a pathology model (122) and a patient-specific biological parameter history (124) to optimize the applied therapy.
Claims43
A therapy prescription apparatus which uses a pathology model and a subject-specific biological parameter history to establish a desired therapy to be applied to the subject, wherein the pathology model models a response of a pathology to a therapy and the biological parameter history includes a biological parameter value obtained from a functional imaging examination of the subject.
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A therapy prescription method including using a pathology model and a subject-specific biological parameter history to establish a desired therapy to be applied to the subject, wherein the pathology model models a response of a pathology to a therapy and the biological parameter history includes spatially varying biological parameter values obtained from a functional imaging examination of the subject.
A therapy prescription apparatus which calculates a therapy to be applied to a pathology based on:
- a desired biological parameter value;
- measured values of the biological parameter;
- and
- a pathology model which models the response of a pathology to a therapy,
- wherein the biological parameter is measured following the application of a therapy to the pathology and the measured values include spatially varying biological parameter values.
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A computer readable storage medium containing instructions which, when carried out by a computer, cause the computer to carry out a method which includes using a desired biological parameter value, a subject-specific measured biological parameter history, and a pathology model to establish a desired therapy to be applied to a pathology of the subject.
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An apparatus comprising:
- a therapy planning system which establishes a characteristic of successive therapies applied to a subject as a function of a desired biological parameter value of the subject, a subject specific biological parameter history indicative of a pathology of the subject, and a pathology model which models response of the pathology to a therapy;
- a therapy device operatively electrically connected to the therapy planning system so as to receive the established characteristic, and wherein the therapy device applies a therapy according to the established characteristic.
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A method comprising:
- obtaining data representative of a measured response of a patient population to an applied therapy, the data including a first measured biological parameter value, the applied therapy, and a second measured biological parameter value representative of a response to the applied therapy, wherein the first and second measured biological parameter values are obtained from functional imaging examinations of members of the subject population;
- storing the data in a computer readable storage medium;
- making the data available to a therapy planning system over a computer network.
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Dependencies are inferred from the claim text.