Methods and Compositions to Inhibit P2x7 Receptor Expression
AssigneeSylentis S.A.
InventorsAna I. Jimenez, Angela Sesto, Jose P. Roman, Irene Gascon, Gonzalo Gonzalez De Buitrago, Maria C. Jimenez
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Abstract
Methods and compositions for the downregulation of P2X7 receptor expression or activity are disclosed. Preferred compositions comprise siNA. The methods and compositions are useful in the treatment of diseases characterised by increased 112X7 receptor activity, such as neuronal degeneration, Alzheimer's disease, inflammatory diseases, and some cancers.
Claims38
Use of siNA in the preparation of a medicament for use in a method of treatment of a condition characterised by increased expression and/or activity of P2RX7, the method comprising downregulating expression of P2RX7 in a patient.
A method of treatment of a disease condition characterised by increased expression and/or activity of P2RX7, comprising administering siNA to downregulate expression of P2RX7 gene in a patient.
An isolated siNA molecule for use in the treatment of a disease condition characterized by increased expression and/or activity of P2RX7, the siNA being complementary to a nucleotide sequence selected from SEQ ID 1 to SEQ ID 109.
Use of an isolated siNA molecule having a sequence which is complementary to a nucleotide sequence selected from SEQ ID 1 to SEQ ID 109 in the preparation of a medicament for the treatment of a disease condition.
A pharmaceutical composition comprising siNA having a sequence which is complementary to a nucleotide sequence selected from SEQ ID 1 to SEQ ID 109.
Method for the treatment of a condition associated with, or mediated by, an increase of extra cellular calcium, comprising downregulation of P2RX7 gene expression by administering to a subject a pharmaceutically effective preparation for causing RNAi.
A method for the detection of a pharmacological activity in a biological sample comprising administering a sample to a cell, and determining a change in activity of P2RX7.
Dependencies are inferred from the claim text.