Organic Compounds

A compound of the formula (I):

• where Q is
• where X3 is
• wherein
• X1 and X2 are independently selected from S, CH2CH2, CH:CH2 or CH20;
• Ar1 is a phenyl, pyridyl, diazinyl or triazinyl group optionally substituted by one or two moieties selected from methyl, ethyl, fluorine, chlorine, bromine, cyano, methoxy, ethoxy, methoxymethyl, trifluoromethyl, trifluoromethoxy, methylthio, ethylthio or methylsulforyl;
• Ar2 is C3-C10-cycloalkyl, a thienyl group or a phenyl group optionally substituted by one or two moieties selected from methyl, ethyl, fluorine, chlorine, bromine, cyano, methoxy, ethoxy, methoxymethyl, trifluoromethyl, trifluoromethoxy, methylthio, ethylthio or methylsulforyl;
• in compounds wherein R1 is an optionally substituted phenyl group, Ar2 may be directly linked to R1 by a CH2, CH2CH2, CH:CH, OCH2 or CH2O group;
• Ar3 is C3-C10-cycloalkyl, a thienyl group or a phenyl group substituted by one or two moieties selected from methyl, ethyl, fluorine, chlorine, bromine, cyano, methoxy, ethoxy, methoxymethyl, trifluoromethyl, trifluoromethoxy, methylthio, ethylthio, methylsulfonyl;
• in compounds wherein Ar2 is an optionally substituted phenyl group R may be linked to Ar2 by a CH2, CH2CH2, CH:CH, OCH2 of CH2O group.
• Ar4 is a biphenyl group optionally substituted by one or two moieties selected from fluorine, chlorine, bromine, methyl, ethyl, cyano, methoxy, ethoxy, methoxymethyl, trifluoromethyl, trifluoromethoxy, methylthio, ethylthio or methylsulforyl;
• n is 0, 1 or 2;
• L is a hydrocarbon linking group of 2 to 20 carbon atoms which may be optionally interrupted by O, N, or CO, and is aptly a group of the form:
• Y1—Y2—Y3
• wherein:
• Y2 is not present or is a group of the formula CH—Y4-Q or —N—Y4-Q where Q independently is a group as defined above and Y4 is a bond or a hydrocarbon linking group of 1 to 8 carbon atoms optionally interrupted by O, NH or CO;
• Y1 is attached to the NH group shown is formula (I) and is a hydrocarbon linking group of 2 to 20 carbon atoms optionally containing an ether oxygen atom or;
• Y3 is not present or is selected from 0 or a group NR2 where R2 is a hydrogen atom or an alkyl group of 2 to 3 carbon atoms optionally linked to a carbon atom within Y1 or Y2 to form a ring or 4, 5, 6 or 7 ring atoms;
• and
• represents a group of the formula:
• or a pharmaceutically acceptable salt thereof.