Condensed Pyridines as Kinase Inhibitors

A compound of general formula I

• wherein:
• A represents C or N;
• B, D and E independently represent CR4, NR5, N, O or S;
• with the following provisos:
• a) when one of B, D or E represents O or S, the other two cannot represent O or S;
• b) when A represents N, none of B, D, E can represent O or
• S;
• and
• c) when A represents C, B represents CR4 and one of D or E represents N or NR5, then the other of D or E cannot represent NR5 or N;
• G represents N or C;
• R1 represents one or more substituents selected from H, Ra, halogen, —CN, —OH and —ORa;
• R2 represents one or more substituents selected from H, halogen and C1-6alkyl, and additionally one substituent R2 can also represent —ORb′, —NO2, —CN, —CORb′, —CO2Rb′, —CONRb′Rb′, —NRb′Rb′, —NRb′CORb′, —NRb′CONRb′Rb′, —NRb′CO2Rb, —NRb′SO2Rb, —SRb′, —SORb, —SO2Rb, —SO2NRb′Rb′ or C1-6alkyl optionally substituted with one or more substituents Rc;
• R3 represents:
• H,
• C1-6 alkyl optionally substituted with one or more substituents selected from Rc and Rd, or
• Cy optionally substituted with one or more substituents selected from Rc, Rd and C1-6alkyl optionally substituted with one or more substituents selected from Rc and Rd;
• each R4 independently represents H, Re, halogen, —ORe′, —NO2, —CN, —CORe′, —CO2Re′, —CONRe′Re′, —NRe′Re′, —NRe′CORe′, —NRe′CONRe′Re′, —NRe′CO2Re, —NRe′SO2Re, —SRe′, —SORe, —SO2Re or —SO2NRe′Re′;
• R5 independently represents H, Re, —CORe, —CONReRe, —SORe or —SO2Re;
• each Ra independently represents C1-6alkyl or haloC1-6alkyl;
• each Rb independently represents C1-6alkyl or Cy, wherein both groups can be optionally substituted with one or more substituents selected from Rd and Rf;
• each Rb′ independently represents H or Rb;
• each Rc independently represents halogen, —ORg′, —NO2, —CN, —CORg′, —CO2Rg′, —CONRg′Rg′, —NRg′Rg′, —NRg′CORg′, —NRg′CONRg′Rg′, —NRg′CO2Rg, —NRg′SO2Rg, —SRg′, —SORg, —SO2Rg or —SO2NRg′Rg′;
• Rd represents Cy optionally substituted with one or more substituents Rf;
• each Re independently represents C1-6alkyl optionally substituted with one or more substituents selected from Rc and Cy*, or Re represents Cy, wherein any of the groups Cy or Cy* can be optionally substituted with one or more substituents selected from Rc and Rg;
• each Re′ independently represents H or Re;
• each Rf independently represents halogen, Rh, —ORh′, —NO2, —CN, —CORh′, CO2Rh′, —CONRh′Rh′, —NRh′Rh′, —NRh′CORh′, —NRh′CONRh′Rh′, —NRh′CO2Rh, —NRh′SO2Rh, —SRh′, —SORh, —SO2Rh, or —SO2NRh′Rh′;
• each Rg independently represents Rd or C1-6alkyl optionally substituted with one or more substituents selected from Rd and Rf;
• each Rg′ independently represents H or Rg;
• each Rh independently represents C1-6alkyl, haloC1-6alkyl or hydroxyC1-6alkyl;
• each Rh′ independently represents H or Rh;
• and
• Cy or Cy* in the above definitions represent a partially unsaturated, saturated or aromatic 3- to 7-membered monocyclic or 8- to 12-membered bicyclic carbocyclic ring, which optionally contains from 1 to 4 heteroatoms selected from N, S and O, wherein one or more C, N or S atoms can be optionally oxidized forming CO, N+O−, SO or SO2, respectively, and wherein said ring or rings can be bonded to the rest of the molecule through a carbon or a nitrogen atom;
• or a salt thereof.