Pyrrolidinone glucokinase activators

A compound of formula (I):

• wherein:
• X is O, NH or N(lower alkyl);
• R1 is -lower alkyl,
• -cycloalkyl,
• —CH2-cycloalkyl,
• -heterocycloalkyl,
• -aryl, unsubstituted or mono-, bi- or tri-substituted independently with alkenyl, hydroxy, —NH2, halogen, alkoxy, —CF3, —OCF3, —S(CH3), —OCH3, —S(O2)CH3, —CH2-aryl, heteroaryl, cyano, alkoyl, —O-aryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-heterocycloalkyl, unsubstituted lower alkyl, or lower alkyl mono- or bi-substituted with hydroxy,
• —CH2-aryl,
• -heteroaryl, unsubstituted or substituted with lower alkyl or halogen,
• -1-methyl-1H-indazol-4yl,
• -benzooxazol-4-yl
• -2-methyl-benzooxazol-4yl,
• -2,3-dihydro-benzo[1,4]dioxin-5-yl,
• -2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl
• -5,6,7,8-tetrahydro-naphthalen-1-yl,
• -naphthalen-1-yl or
• -isoquinolin;
• R2 is -lower alkyl,
• -ether,
• -alkoxy,
• -cycloalkyl,
• -heterocycloalkyl,
• -aryl, unsubstituted or mono- or bi-substituted independently with halogen, or
• -heteroaryl having at least one ring heteroatom being either O or S;
• and
• R3 is -lower alkyl-carbamoyl or
• -an unsubstituted or substituted heteroaryl connected by a ring carbon atom to the amine group shown, with one heteroatom being nitrogen which is adjacent to the connecting ring carbon atom, said substituted heteroaryl being substituted at a position other than adjacent to said connecting carbon atom independently with halogen, ester, cyano, acid, cycloalkyl, aryl, 2-oxo-oxazolidin-5-ylmethyl, —N(lower alkyl)2, —CH2-dimethyl-[1,3]dioxolane, t-butyl-dimethyl-silanyloxy ethyl, unsubstituted —CH2-aryl, —CH2-aryl substituted with cyano or alkoxy, heterocycloalkyl, —CH2-heterocycloalkyl, -6-(CH2)-2,2-dimethyl-[1,3]dioxan-4-yl-acetic acid tert-butyl ester, unsubstituted lower alkyl, or lower alkyl mono-, bi- or tri-substituted independently with hydroxy, alkoxy, —N(lower alkyl)2, —NH2, ester, acid or carboxamide,
• or a pharmaceutically acceptable salt thereof.