Organic compounds

A method of inhibiting human stearoyl-CoA desaturase (hSCD) activity, comprising:

• contacting a source of hSCD with a compound of Formula (I):
• wherein,
• Q is
• W is —N(R6)C(O)—, —R8—C(O)N(R6)—, —R8—OC(O)N(R6)—, —N(R6)C(O)O—, —N(R6)C(O)N(R6)—-O—, —S—, —N(R6)—, —S(O)t—, —N(R6)S(O)t—, —S(O)tN(R6)—, —OS(O)tN(R6)—, —R8—C(O)—, —OC(O)—, —C(O)O—, —N(R6)C(═N(R6a))N(R6)—, —N(R6)((R6a)N═)C—, —C(═N(R6a))N(R6)—, or a direct bond;
• V is —C(O)N(R6)—, —S(O)t—, —S(O)2N(R6)—, —C(O)—, —R8—C(O)O—, —R8—C(O)N(R6)—, —R8—C(O)—, —C(═N(R6a))N(R6)—, or a direct bond;
• t is 1 or 2;
• R1 is halo, hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl;
• or R1 is a multi-ring structure having 2 to 4 rings wherein the rings are independently cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other;
• R2 is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, hydroxyalkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, aryl, haloalkyl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl;
• or R2 is a multi-ring structure having 2 to 4 rings wherein the rings are independently cycloalkyl, heterocyclyl, aryl or heteroaryl and where some or all of the rings may be fused to each other;
• R3 is hydrogen or alkyl;
• R4 and R4a are independently hydrogen, alkyl, haloalkyl, hydroxyl, hydroxyalkyl, alkoxy, cycloalkylalkyl or aralkyl;
• or R4 and R4a are taken together to form an oxo (═O) group, cycloalkyl or heterocyclyl;
• R5 and R5a are independently hydrogen, alkyl or haloalkyl;
• or R4 and R5 are taken to form a cycloalkyl, aryl, heteroaryl or heterocyclyl, and the remaining R4a and R5a are as described above;
• R6 is independently hydrogen, alkyl, hydroxyalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl or aralkyl;
• R6a is independently hydrogen, alkyl, cycloalkylalkyl, or cyano;
• R7 is hydrogen, alkyl, trifluoromethyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, hydroxyalkyl, cycloalkylalkyl or aralkyl;
• and
• R8 is independently a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain or an optionally substituted straight or branched alkynylene chain;
• as a stereoisomer, enantiomer or tautomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof.