Piperidine and Morpholine Renin Inhibitors

A compound represented by the following structural formula:

• wherein:
• Ga is
• a) (C1-C9)alkyl, (C3-C7)cycloalkyl, (C4-C9)cycloalkylalkyl, halo(C1-C9)alkyl, halo(C3-C7)cycloalkyl, halo(C4-C9)cycloalkylalkyl, saturated heterocyclyl optionally substituted with 1 to 3 groups independently selected from fluorine, (C1-C3)alkyl, halo(C1-C3)alkyl, and oxo;
• or
• b) phenyl, napthyl, heteroaryl, or bicyclic heteroaryl each optionally substituted with 1 to 3 groups independently selected from the groups consisting of:
• 1) fluorine, chlorine, bromine, cyano, nitro, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C4-C7)cycloalkylalkyl, (C2-C6)alkenyl, (C5-C6)cycloalkenyl, (C5-C8)cycloalkylalkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkylethynyl, halo(C1-C6)alkyl, halo(C3-C6)cycloalkyl, halo(C4-C7)-cycloalkylalkyl, halo(C2-C6)alkenyl, halo(C3-C6)alkynyl, halo(C3-C6)cycloalkylethynyl, (C1-C6)alkoxy, (C3-C6)cycloalkoxy, (C4-C7)cycloalkylalkoxy, halo(C1-C6)alkoxy, halo(C3-C6)cycloalkoxy, halo(C4-C7)cycloalkylalkoxy, (C3-C6)alkenyloxy and (C1-C6)alkanesulfonyl;
• or
• 2) phenyl, heteroaryl, phenoxy, heteroaryloxy, phenylthio, heteroarylthio, benzyl, heteroarylmethyl, benzyloxy and heteroaryloxy, each optionally substituted with 1 to 3 groups independently selected from the group consisting of fluorine, chlorine, cyano, (C1-C3)alkyl, halo(C1-C3)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, and aminocarbonyl;
• Gb is hydrogen, (C1-C8)alkyl, (C4-C8)cycloalkylalkyl, fluoro(C1-C8)alkyl, fluoro(C4-C8)cycloalkylalkyl, (C1-C8)alkoxy, (C4-C8)cycloalkylalkoxy, fluoro(C1-C8)alkoxy, hydroxy(C1-C8)alkyl, (C1-C5)alkoxy(C1-C5)alkyl, halo(C1-C5)alkylamino(C1-C5)alkyl, (C1-C5)alkoxy(C1-C5)hydroxyalkyl, (C3-C4)cycloalkoxy(C1-C5)alkyl, fluoro(C1-C5)alkoxy(C1-C5)alkyl, fluoro(C3-C4)cycloalkoxy(C1-C5)alkyl, (C1-C5)alkylthio(C1-C5)alkyl, (C1-C5)alkoxy(C1-C8)alkoxy, hydroxy(C1-C8)alkoxy, (C3-C4)cycloalkoxy(C1-C5)alkoxy, fluoro(C1-C5)alkoxy(C1-C5)alkoxy, fluoro(C3-C4)cycloalkoxy(C1-C5)alkoxy, (C1-C3)alkoxy(C1-C3)alkoxy(C1-C3)alkyl, fluoro(C1-C3)alkoxy(C1-C3)alkoxy(C1-C3)alkyl, aminocarbonylamino(C1-C8)alkyl, aminocarbonylamino(C1-C8)alkoxy, (C1-C5)alkanoylamino(C1-C5)alkyl, (C1-C5)alkanoylamino(C1-C5)alkoxy, fluoro(C1-C5)alkanoylamino(C1-C5)alkyl, fluoro(C1-C5)alkanoylamino(C1-C5)alkoxy, (C1-C3)alkoxy(C1-C8)alkanoylamino(C1-C5)alkyl, (C1-C3)alkoxy(C1-C5)alkanoylamino(C1-C5)alkoxy, (C3-C4)cycloalkanecarbonyllamino(C1-C5)alkyl, (C3-C4)cycloalkanecarbonyllamino(C1-C5)alkoxy, aminosulfonylamino(C1-C8)alkyl, aminosulfonylamino(C1-C8)alkoxy, (C1-C5)alkanesulfonylamino(C1-C5)alkyl, (C1-C5)alkanesulfonylamino(C1-C5)alkoxy, formylamino(C1-C5)alkyl, formylamino(C1-C5)alkoxy, (C1-C5)alkoxycarbonylamino(C1-C5)alkyl, (C1-C5)alkoxycarbonyl-amino(C1-C5)alkoxy, (C1-C5)alkyl aminocarbonylamino(C1-C5)alkyl, (C1-C5)alkylaminocarbonyl-amino(C1-C5)alkyl, di(C1-C5)alkylaminocarbonylamino(C1-C5)alkoxy, aminocarbonyl(C1-C5)alkyl, aminocarbonyl(C1-C5)alkoxy, (C1-C5)alkylaminocarbonyl (C1-C8)alkyl, (C1-C5)alkylaminocarbonyl-(C1-C5)alkoxy, aminocarboxy(C1-C5)alkyl, aminocarboxy(C1-C5)alkoxy, (C1-C8)alkylamino-carboxy(C1-C5)alkyl, (C1-C5)alkylaminocarboxy(C1-C5)alkoxy, (C1-C8)alkoxycarbonylamino, (C1-C8)alkylaminocarbonylamino, (C1-C8)alkanoylamino, fluoro(C1-C8)alkoxycarbonylamino, fluoro(C1-C8)alkylaminocarbonylamino, or fluoro(C1-C8)alkanoylamino;
• Gc is —H, halogen, OH, (C1-C4)alkanoylamino, or (C1-C3)alkoxy;
• provided that
• i) Gb and Gc are not both hydrogen and
• ii) when Gc is OH or halogen, Gb is not (C1-C8)alkoxy, (C4-C8)cycloalkylalkoxy, fluoro(C1-C8)alkoxy, (C1-C5)alkoxy(C1-C5)alkoxy, hydroxy(C1-C8)alkoxy, (C3-C4)cycloalkoxy(C1-C5)alkoxy, fluoro(C1-C5)alkoxy(C1-C5)alkoxy, fluoro(C3-C4)cycloalkoxy(C1-C5)alkoxy, aminocarbonylamino(C1-C8)alkoxy, (C1-C5)alkanoyl-amino(C1-C5)alkoxy, fluoro(C1-C5)alkanoylamino(C1-C5)alkoxy, (C1-C3)alkoxy(C1-C5)alkanoyl-amino(C1-C5)alkoxy, (C3-C4)cycloalkanecarbonyllamino(C1-C5)alkoxy, aminosulfonylamino(C1-C8)alkoxy, (C1-C5)alkanesulfonylamino(C1-C5)alkoxy, formylamino(C1-C5)alkoxy, (C1-C5)alkoxy-carbonylamino(C1-C5)alkoxy, di(C1-C5)alkylaminocarbonylamino(C1-C5)alkoxy, aminocarbonyl(C1-C5)alkoxy, (C1-C5)alkylaminocarbonyl(C1-C5)alkoxy, aminocarboxy(C1-C5)alkoxy, (C1-C5)alkylaminocarboxy(C1-C5)alkoxy, (C1-C8)alkoxycarbonylamino, (C1-C8)alkylaminocarbonylamino, (C1-C8)alkanoylamino, fluoro(C1-C8)alkoxycarbonylamino, fluoro(C1-C8)alkylaminocarbonylamino, or fluoro(C1-C8)alkanoylamino;
• A4 is CH2 or O;
• Q is a divalent radical selected from:
• T is a mimic of the Leu-Val cleavage site of angiotensinogen or an enantiomer, diastereomer or salt thereof.