Extended release dosage forms of quetiapine
OwnerInder Gulati, Rajan Kumar Verma +4inventors
InventorsInder Gulati, Rajan Kumar Verma, Rajeev Singh Raghuvanshi, Romi Barat Singh, Kumaravel Vivek, Sweta Varshney
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Abstract
The present invention relates to an extended release dosage form of quetiapine wherein the dosage form comprises quetiapine and rate-controlling polymer selected from polyethylene oxide, sodium alginate and natural gum and combinations thereof. The dosage form may additionally comprise at least one water-insoluble polymer.
Claims10
An extended release dosage form comprising quetiapine and a rate-controlling polymer selected from polyethylene oxide, sodium alginate and natural gum and combinations thereof and other pharmaceutically acceptable excipients.
The extended release dosage form of quetiapine according to any of the preceding claims, wherein the dosage form exhibits the following in vitro dissolution profile, when measured in a USP dissolution apparatus type I, at 100 rpm, at a temperature of 37±0.5° C. in 900 ml of 0.1N hydrochloric acid;
- at most about 50% of the drug is released in 2 hours;
- at most about 75% of the drug is released in 4 hours and
- at most about 99% of the drug is released in 8 hours.
Dependencies are inferred from the claim text.