US 2009/0264406 A1Published application

3-methyl-imidazo[1,2-b]pyridazine derivatives

AssigneeNovartis AG

InventorsPascal Furet, Clive McCarthy, Joseph Schoepfer, Carsten Spanka, Melanie Stang, Frederic Stauffer

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Abstract

The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).

Claims21

Dependent claims

A compound of the formula (I),

wherein
R1 represents unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted alkyl, unsubstituted or substituted alkoxy, cyano, carboxamide, or halogen;
R2 represents unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl;
R3 represents H, deuterium, lower alkyl and R3′ represents H, deuterium, lower alkyl, halogen, hydroxy or
R3 represents halogen and R3′ represents halogen or
R3 and R3′ represent, together with the carbon atom to which they are attached, cycloalkyl or vinyl;
A1 represents either a direct bond, an —SO2— group, or a group
wherein the bond marked * is attached to R1,
n represents 0 or 1;
m represents 0, 1, 2, 3, 4 or 5;
R4 represents H or unsubstituted alkyl;
R5 represents H or unsubstituted alkyl;
R5′ represents H or unsubstituted alkyl;
A2 represents O or NR4;
or a salt thereof.

12 more elements

A compound selected from:

(rac)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-quinolin-6-ylmethanol;
6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
(rac)-(4-Methoxy-phenyl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
3-(4-methoxy-benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
4-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-phenol;
6-{Difluoro-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methyl}-quinoline;
6-[6-(1-Piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-Benzofuran-5-ylmethyl-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(rac)-Imidazo[1,2-a]pyridin-6-yl-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
3-Imidazo[1,2-a]pyridin-6-ylmethyl-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(rac)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-quinoxalin-6-ylmethanol;
3-Benzothiazol-6-ylmethyl-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(2-Methyl-benzothiazol-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-quinoline;
2-Chloro-4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
6-(6-p-Tolyl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Naphthalen-2-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(3-Trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(4-Bromo-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenylamine;
1-[4-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-ethanone;
6-[6-(3-Nitro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(4-Methylsulfanyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzaldehyde;
6-[6-(4-Fluoro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzonitrile;
6-[6-(4-Chloro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
N-[3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-acetamide;
6-(6-Pyridin-3-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Phenyl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Benzofuran-2-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Naphthalen-1-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(4-Trifluoromethyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(3-Phenyl-isoxazol-5-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
6-[6-(4-Methoxy-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
Dimethyl-[3-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-amine;
6-[6-(1-Methyl-1H-indol-5-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-(6-Benzo[b]thiophen-2-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Quinolin-3-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(6-Methoxy-naphthalen-2-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(5-Chloro-thiophen-2-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-(6-Isoquinolin-4-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(4-Trifluoromethoxy-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(4-Butyl-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(1H-Indol-5-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(1-Propyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(6-Chloro-pyridin-3-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6′-Chloro-5-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-[2,3′]bipyridinyl;
6-[6-(2-Chloro-pyridin-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
2′-Chloro-4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-[2,4′]bipyridinyl;
6-(6-Benzo[1,3]dioxol-5-yl-imidazo[1,2-b]pyridazin-3-yl methyl)-quinoline;
6-(6-Benzo[1,2,5]oxadiazol-5-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(3-Chloro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-(6-Pyrimidin-5-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
1-[3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-ethanone;
6-[6-(2-Methoxy-pyrimidin-5-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
N-Methyl-3-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
N,N-Dimethyl-3-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzoic acid ethyl ester;
6-[6-(1H-Indol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(6-Methoxy-pyridin-3-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
6-[6-(2,3-Dihydro-benzofuran-5-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-[4-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-phenyl]-propan-1-ol;
6-(6-Thiophen-3-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
N-(2-Dimethylamino-ethyl)-3-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)benzamide;
2-Fluoro-5-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzonitrile;
6-[6-(3-Chloro-4-fluoro-phenyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(2H-Pyrazol-3-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
2-Fluoro-N-methyl-4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
2-Chloro-N-methyl-4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
3-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-benzoic acid;
5-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyridin-2-ol;
6-Chloro-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine;
2-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-ylamino)-ethanol;
[(R)-1-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-dimethyl-amine;
(rac)-(6-Isobutylamino-imidazo[1,2-b]pyridazin-3-yl)-quinolin-6-yl-methanol;
sec-Butyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Isobutyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-(tetrahydro-furan-2-ylmethyl)amine;
Cyclopentyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Benzyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(1-Methyl-piperidin-4-yl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
6-(6-Morpholin-4-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-(6-Pyrrolidin-1-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
Dimethyl-[1-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-piperidin-4-yl]-amine;
Methyl-[1-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester;
Dimethyl-[(R)-1-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-amine;
(2-Methoxy-ethyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(1-Ethyl-propyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Isopropyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
2-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-ylamino)-ethanol;
4-Methyl-thiazol-2-yl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(2-Pyrrolidin-1-yl-ethyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(1-Ethyl-pyrrolidin-2-ylmethyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)amine;
N-[2-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-ylamino)-ethyl]-acetamide;
Cyclooctyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(1,1-Dimethyl-propyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
1,1-Dioxo-tetrahydro-1 lambda*6*-thiophen-3-yl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(2-Phenyl-propyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
N,N-Dimethyl-N′-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-propane-1,3-diamine;
4-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-piperazin-2-one;
(1-Phenyl-ethyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Phenethyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
[Methyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amino]-acetic acid;
Dimethyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(S)-1-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-ol;
(R)-1-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-ol;
1-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-[1,4]diazepan-5-one;
6-[6-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(2-Methyl-piperidin-1-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
6-[6-(3-Chloro-phenylsulfanyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(3-Chloro-phenoxy)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-(2,2,2-trifluoro-ethyl)-amine;
6-(6-Imidazol-1-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(2-Methyl-imidazol-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(1-Benzyl-pyrrolidin-3-yl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
6-[6-(4-Methyl-imidazol-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(rac)-Methyl-[1-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrrolidin-3-yl]-amine;
1-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-piperidin-4-one;
(3-Chloro-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Phenyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
6-(6-ethoxy-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-((R)-3-fluoro-pyrrolidin-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-((S)-3-Fluoro-pyrrolidin-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(4-Piperidin-1-ylmethyl-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)amine;
(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-(3-trifluoromethyl-phenyl)amine;(2-Chloro-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Pyridin-3-yl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Pyrimidin-2-yl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Pyrimidin-4-yl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(2-Ethyl-2H-pyrazol-3-yl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
7-[6-(4-Methyl-pyrazol-1-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-(6-Pyrazol-1-yl-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
(3-Chloro-4-methyl-phenyl)-(3-quinolin-7-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)amine;
(2,3-Dichloro-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(3-Chloro-4-fluoro-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(3-Chloro-phenyl)-methyl-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
(3-Methanesulfonyl-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)amine;
(3-Methoxy-phenyl)-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-amine;
Benzo[1,2,5]oxadiazol-4-yl-(3-quinolin-7-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)amine;
6-[(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-dideutero-methyl]-quinoline;
6{Dideutero-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]}-quinoline;
2-Chloro-N-(2-pyrrolidin-1-yl-ethyl)-4-(3-quinolin-6-yl methyl-imidazo[1,2-b]pyridazin-6-yl)-benzamide;
6-[6-(3-Chloro-benzenesulfonyl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
7-Fluoro-6-{6-[1-(1-methyl-azetidin-3-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-Imethyl}-quinoline;
2-(4-{4-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-piperidin-1-yl)-ethanol;
6-{6-[1-(1-Ethyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-7-fluoro-quinoline;
7-Fluoro-6-(6-{1-[1-(2,2,2-trifluoro-ethyl)-piperidin-4-yl]-1H-pyrazol-4-yl}-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
3-(1H-Indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(R)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-quinolin-6-ylmethanol;
(S)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-quinolin-6-yl-methanol;
(rac)-2 ,2 ,2-Trifluoro-N-(6-{hydroxy-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methyl}-imidazo[1,2-a]pyridin-2-yl)-acetamide;
6-[1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-vinyl]-quinoline;
6-{1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-vinyl}-quinoline;
(rac)-6-{1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-1,2,3,4-tetrahydro-quinoline;
(rac)-6-{1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
6-{(R)-1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
6-{(S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
5-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(rac)-(2-Amino-imidazo[1,2-a]pyridin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
3-(1H-Benzoimidazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
6-{1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-cyclopropyl}-quinoline;
(rac)-3-[1-(6-Fluoro-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-[(S)-1-(6-Fluoro-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-[(R)-1-(6-Fluoro-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(6-Fluoro-1H-indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(rac)-2,2,2-Trifluoro-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-1-quinolin-6-yl-ethanol;
6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-7-trifluoromethyl-quinoline;
5,7-Difluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
2-{4-[3-(5,7-Difluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
7-Fluoro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(rac)-1-(7-Fluoro-quinolin-6-yl)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethanol;
(R)-1-(7-Fluoro-quinolin-6-yl)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethanol;
[4-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-acetonitrile;
(rac)-2-{4-[3-(1-Quinolin-6-yl-ethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
2-{4-[3-((R)-1-Quinolin-6-yl-ethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
2-{4-[3-((S)-1-Quinolin-6-yl-ethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
7-Fluoro-6-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
7-Fluoro-6-{6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
(rac)-2-(4-{3-[1-(5,7-Difluoro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(R)-1-(5,7-Difluoro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(S)-1-(5,7-Difluoro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
(rac)-2-(4-{3-[1-(3-Methyl-3H-benzoimidazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(R)-1-(3-Methyl-3H-benzoimidazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(S)-1-(3-Methyl-3H-benzoimidazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
(rac)-2-(4-{3-[1-(5-Chloro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
(rac)-2-{4-[3-(1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
(rac)-2-(4-{3-[1-(2H-Indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)ethanol;
(rac)-5,7-Difluoro-6-{1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
5,7-Difluoro-6-{(S)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
5,7-Difluoro-6-{(R)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
3-[(S)-1-(6-Fluoro-1-methyl-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
3-[(S)-1-(2H-Indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-[(S)-1-(1-Methyl-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
6-{Difluoro-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methyl}-quinoline;
6-[2-Methyl-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-(1-Methyl-1H-pyrazol-4-yl)-3-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-imidazo[1,2-b]pyridazine;
3-(3-Methyl-3H-benzoimidazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
6-(1-Methyl-1H-pyrazol-4-yl)-3-[3-(2-pyrrolidin-1-yl-ethyl)-3H-benzoimidazol-5-ylmethyl]-imidazo[1,2-b]pyridazine;
3-Fluoro-4-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-phenol;
3-(4-Bromo-2-fluoro-benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(2,4-Difluoro-benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(7-Fluoro-imidazo[1,2-a]pyridin-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
(rac)-3-[1-(3-Methyl-3H-benzoimidazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
(rac)-6-(1-Methyl-1H-pyrazol-4-yl)-3-{1-[3-(2-pyrrolidin-1-yl-ethyl)-3H-benzoimidazol-5-yl]-ethyl}-imidazo[1,2-b]pyridazine;
3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazine-6-carbonitrile;
3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazine-6-carboxamide;
2-[4-(3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethanol;
6-(6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
6-[6-(1-Ethyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
6-[6-(1H-Pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazine-6-carboxylic acid ethylamide;
3-Quinolin-6-ylmethyl-imidazo[1,2-b]pyridazine-6-carboxylic acid methylamide;
2-[4-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethanol;
2-[4-(3-Imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethanol;
2-{4-[3-(3-Methyl-3H-benzoimidazol-5-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
2-(4-{3-[3-(2-Pyrrolidin-1-yl-ethyl)-3H-benzoimidazol-5-ylmethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
3-Fluoro-4-{6-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-phenol;
4-{6-[1-(2-Hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-phenol;
(rac)-4-(1-{6-[1-(2-Hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethyl)-phenol;
(rac)-4-{1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-phenol;
(rac)-5-Chloro-6-{1-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
5-Chloro-6-(1-{6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethyl)-quinoline;
(rac)-5-Chloro-6-{1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
2-{4-[3-(5-Chloro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
5-Chloro-6-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
5-Chloro-6-{6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
(rac)-(3-Methyl-3H-benzoimidazol-5-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
1-(4-{4-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-piperidin-1-yl)-ethanone;
7-Fluoro-6-{6-[1-(2-pyrrolidin-1-yl-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
7-Fluoro-6-{6-[1-(2-morpholin-4-yl-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
7-Fluoro-6-(6-{1-[2-(2-methoxy-ethoxy)-ethyl]-1H-pyrazol-4-yl}-imidazo[1,2-b]pyridazin-3-ylmethyl)-quinoline;
7-Fluoro-6-{6-[1-(2-methoxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
6-{6-[1-(2-Azetidin-1-yl-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl methyl}-quinoline;
6-{6-[1-(2-Pyrrolidin-1-yl-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
Methyl-{2-[4-(3-quinolin-6-ylmethyl-imidazo[1,2-b]pyridazin-6-yl)-pyrazol-1-yl]-ethyl}-amine;
6-{6-[1-(1-Methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
6-((S)-1-{6-[1-(1-Methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethyl)-quinoline;
6-{(S)-1-[6-(1H-Pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
7-Chloro-6-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
7-Chloro-6-[6-(1-ethyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-quinoline;
2-{4-[3-(7-Chloro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
4-{4-[3-(5,7-Difluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-piperidine-1-carboxylic acid tert-butyl ester;
5,7-Difluoro-6-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
5,7-Difluoro-6-{6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-ylmethyl}-quinoline;
(rac)-(5-Fluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
(rac)-7-Fluoro-quinolin-6-yl)-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
(rac)-[6-(1-Ethyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-(7-fluoro-quinolin-6-yl)methanol;
6-[6-(1-Ethyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-7-fluoro-quinoline;
7-Fluoro-6-[6-(1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(rac)-(7-Fluoro-quinolin-6-yl)-[6-(1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-methanol;
(rac)-7-Fluoro-6-{1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
2-{4-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
(rac)-2-(4-{3-[1-(7-Fluoro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
3-((R)-1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-((R)-1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(rac)-7-Fluoro-6-{1-[6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-quinoline;
(rac)-7-Fluoro-6-(1-{6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethyl)-quinoline;
(rac)-{1-[3-(7-fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrrolidin-3-yl}-methyl-amine;
(S)-1-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrrolidin-3-ol;
(R)-1-[3-(7-Fluoro-quinolin-6-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrrolidin-3-ol;
5,7-Difluoro-6-[6-(1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-quinoline;
(rac)-1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-1-quinolin-6-yl-ethanol;
(rac)-1-(7-Fluoro-quinolin-6-yl)-1-{6-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethanol;
(R)-1-(7-Fluoro-quinolin-6-yl)-1-{6-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethanol;
(rac)-1-(5,7-Difluoro-quinolin-6-yl)-1-{6-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethanol;
(R)-1-(5,7-Difluoro-quinolin-6-yl)-1-{6-[1-(2-hydroxy-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazin-3-yl}-ethanol;
(rac)-1-(5,7-Difluoro-quinolin-6-yl)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethanol;
(R)-1-(5,7-Difluoro-quinolin-6-yl)-1-[6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethanol;
(rac)-6-[1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-quinoline;
6-[(R)-1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-quinoline;
6-[(S)-1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-ethyl]-quinoline;
(rac)-6-[1-(6-Chloro-imidazo[1,2-b]pyridazin-3-yl)-2,2,2-trifluoro-ethyl]-quinoline;
2-(5-{(S)-1-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-ethyl}-indazol-1-yl)-ethanol;
3-(1-Methyl-1H-indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(6-Fluoro-1-methyl-1H-indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
(rac)-3-[1-(6-Fluoro-1-methyl-1H-indazol-5-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
(rac)-2-(4-{3-[1-(6-Fluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(S)-1-(6-Fluoro-1-methyl-1H-indazol-5-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-{4-[3-(6-Fluoro-1-methyl-1H-indazol-5-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
3-(6-Fluoro-1-methyl-1H-indazol-5-ylmethyl)-6-(1-piperidin-4-yl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
3-(6-Fluoro-1-methyl-1H-indazol-5-ylmethyl)-6-[1-(1-methyl-piperidin-4-yl)-1H-pyrazol-4-yl]-imidazo[1,2-b]pyridazine;
3-(4,6-Difluoro-1-methyl-1H-indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
2-{4-[3-(4,6-Difluoro-1-methyl-1H-indazol-5-ylmethyl)-imidazo[1,2-b]pyridazin-6-yl]-pyrazol-1-yl}-ethanol;
(rac)-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl]-[1,5]naphthyridin-2-yl-methanol;
3-(3-Methyl-1H-indazol-5-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(2-Fluoro-imidazo[1,2-a]pyridin-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
6-(1-Ethyl-1H-pyrazol-4-yl)-3-imidazo[1,2-a]pyridin-6-ylmethyl-imidazo[1,2-b]pyridazine;
3-Imidazo[1,2-a]pyridin-6-ylmethyl-6-(1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-Imidazo[1,2-a]pyridin-6-ylmethyl-6-(1-piperidin-4-yl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
(rac)-6-Chloro-3-(1-imidazo[1,2-a]pyridin-6-yl-ethyl)-imidazo[1,2-b]pyridazine;
(rac)-3-(1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-((R)-1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-((S)-1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazine;
3-(3-Bromo-imidazo[1,2-a]pyridin-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-imidazo[1,2-a]pyridine-3-carbaldehyde;
3-(3-Chloro-imidazo[1,2-a]pyridin-6-ylmethyl)-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
6-(1-Methyl-1H-pyrazol-4-yl)-3-(3-vinyl-imidazo[1,2-a]pyridin-6-yl methyl)-imidazo[1,2-b]pyridazine;
{6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-imidazo[1,2-a]pyridin-3-yl}-methanol;
1-{6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-imidazo[1,2-a]pyridin-3-yl}-ethanone;
6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-yl methyl]-imidazo[1,2-a]pyridine-3-carbonitrile;
1-{6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-imidazo[1,2-a]pyridin-3-yl}-ethanol;
1-{6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-imidazo[1,2-a]pyridin-3-yl}-ethane-1,2-diol;
3-{6-[6-(1-Methyl-1H-pyrazol-4-yl)-imidazo[1,2-b]pyridazin-3-ylmethyl]-imidazo[1,2-a]pyridin-3-yl}-benzonitrile;
6-(1-Methyl-1H-pyrazol-4-yl)-3-(3-pyridin-3-yl-imidazo[1,2-a]pyridin-6-ylmethyl)imidazo[1,2-b]pyridazine;
6-(1-Methyl-1H-pyrazol-4-yl)-3-[3-(1-methyl-1H-pyrazol-4-yl)-imidazo[1,2-a]pyridin-6-ylmethyl]-imidazo[1,2-b]pyridazine;
(rac)-3-(1-Imidazo[1,2-a]pyridin-6-yl-ethyl)-6-m-tolyl-imidazo[1,2-b]pyridazine;
(rac)-3-[1-(3-Bromo-imidazo[1,2-a]pyridin-6-yl)-ethyl]-6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazine;
(rac)-2-(4-{3-[1-(3-Bromo-imidazo[1,2-a]pyridin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
2-(4-{3-[(S)-1-(3-Bromo-imidazo[1,2-a]pyridin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-pyrazol-1-yl)-ethanol;
(rac)-3-[1-(3-Bromo-imidazo[1,2-a]pyridin-6-yl)-ethyl]-6-m-tolyl-imidazo[1,2-b]pyridazine.

308 more elements

Dependencies are inferred from the claim text.