Highly fluorinated oils and surfactants and methods of making and using same
AssigneeUniversity of Utah Research Foundation
InventorsYihua Yu, Zhong-Xing Jiang
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Abstract
Disclosed are compounds comprising the structure: In one aspect, the compounds exhibit maximum symmetric branching. Also disclosed are bilayers, micelles, coatings, and nanoparticles comprising the disclosed compounds. Also disclosed are processes for the preparation of the disclosed compounds and methods of using the disclosed compounds. Also disclosed are highly fluorinated dendrons and methods for making same. Also disclosed are methods for Fluorous Mixture Synthesis and tagging. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims27
A compound comprising the structure:
- wherein p is a non-negative integer;
- wherein R11, R12, R13, R21, R22, R23, R31, R32, and R33 are, independently, H, CH3, CF3 or alkyl;
- and
- wherein R4 is H, OH, OBn, OC(CF3)3, alkyl, or alkoxy.
A compound of claim 0, comprising the structure:
A compound of claim 0, wherein R11, R12, R13, R21, R22, R23, R31, R32, and R33 are CF3.
A compound of claim 0, comprising the structure:
- wherein R11, R12, R13, R21, R22, R23, R31, R32, and R33 are, independently, H, CH3, CF3 or alkyl;
- and
- wherein R4 is H, OH, OBn, OC(CF3)3, alkyl, or alkoxy.
7-9. (canceled)
A compound of claim 0, wherein the compound exhibits maximum symmetric branching.
16-20. (canceled)
A process for the preparation of a compound comprising the structure:
- wherein R is H, CH3, CF3 or alkyl and wherein R4 is H, OH, OBn, alkyl, or alkoxy;
- the process comprising the steps of:
- providing a triol,
- reacting the triol with tert-butanol or nonafluoro-tert-butanol to provide a tri-tert-butyl ether or a triperfluoro-tert-butyl ether.
22-33. (canceled)
The process of claim 0, wherein R is CF3.
The process of claim 0, wherein n is an integer from 4 to 12.
37-54. (canceled)
The method of claim 101, comprising the steps of:
- a. complexing a radionuclide with a compound of claim 1;
- and
- b. administering the complex to a mammal in an amount effective for radiotherapy.
(canceled)
The method of claim 101, comprising the steps of:
- a. complexing a metal ion with a compound of claim 1;
- and
- b. administering the complex to a subject in an amount effective for detection by 1H MRI.
58-64. (canceled)
66-100. (canceled)
Dependencies are inferred from the claim text.