Fluocinolone Implants to Protect Against Undesirable Bone and Cartilage Destruction
AssigneeWarsaw Orthopedic, Inc.
InventorVanja Margareta KING
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Abstract
Effective treatments for protecting against undesirable macrophage activity are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce or prevent macrophage activity. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to prevent transplant rejection for at least thirty days. In some embodiments, the relief can be for at least sixty days, or up to ninety days.
Claims20
An implantable drug depot for preventing or reducing pathological bone and/or cartilage destruction in a patient in need of such treatment, the implantable drug depot comprising fluocinolone in an amount from about 300 micrograms to about 350 micrograms, and at least one biodegradable polymer, wherein the drug depot is capable of releasing fluocinolone or pharmaceutically acceptable salt thereof over a period of at least thirty days.
A method of treating arthritis in a mammal suffering there from, the method comprising locally administering to an affected joint, a biodegradable drug depot comprising fluocinolone, wherein the fluocinolone reduces destruction of bone and/or cartilage of the affected joint.
Dependencies are inferred from the claim text.