Inhibitor of Adenylyl Cyclase for Treating a Disorder of the Circadian Rhythm
AssigneeMedical Research Council
InventorsMichael Hastings, Elizabeth Maywood, John O'Neill
Life of this patent
Estimating the term…
Abstract
The invention relates to use of a composition comprising an inhibitor of adenylyl cyclase in the elongation of circadian rhythm, a method of extending the period of circadian rhythm in a subject, said method comprising administering to said subject an inhibitor of adenylyl cyclase, and to adenylyl cyclase inhibitor for use in the treatment of a disorder of the circadian rhythm. Preferably the inhibitor is a P-site inhibitor, preferably 9-(tetrahydrofuryl)-adenine. The composition may further comprise a JNK inhibitor.
Claims17
(canceled)
A method of extending the period of circadian rhythm in a subject, said method comprising administering to said subject a composition comprising an inhibitor of adenylyl cyclase, wherein said inhibitor of adenylyl cyclase is a purine site (p-site) inhibitor.
A method of modifying the circadian rhythm in a subject comprising administering to said subject a composition comprising an inhibitor of adenylyl cyclase, wherein said inhibitor of adenylyl cyclase is a purine site (p-site) inhibitor.
14-24. (canceled)
A pharmaceutical pack or kit comprising
- (i) an adenylyl cyclase inhibitor, and
- (ii) a JNK-inhibitor.
Dependencies are inferred from the claim text.