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OwnerLinda Saxe Einbond, Morando Soffritti +7inventors
InventorsLinda Saxe Einbond, Morando Soffritti, Kyle Louis Kolaja, Richard John Brennan, I. Bernard Weinstein, Joan Weinstein, Tamara Weinstein, Claudia Weinstein, Matthew Weinstein
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A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.
A method for treating, preventing or ameliorating breast cancer comprising administering to a patient in need thereof a composition comprising a synergistic amount of a statin and an extract of black cohosh comprising a triterpene glycoside, and a pharmaceutically acceptable carrier, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A method for treating, preventing or ameliorating breast cancer comprising administering to a patient in need thereof a composition comprising a synergistic amount of a statin and actein, and a pharmaceutically acceptable carrier, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A method for treating, preventing or ameliorating neoplasia in a subject comprising administering to the subject an amount of an extract of black cohosh comprising a triterpene glycoside, which amount of the black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A method for treating, preventing or ameliorating neoplasia in a subject comprising administering to the subject an amount of actein effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A composition for use in treating, preventing or ameliorating neoplasia comprising an effective anti-neoplastic amount of an extract of black cohosh comprising a triterpene glycoside and an effective anti-neoplastic amount of a statin, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A composition for treating, preventing or ameliorating neoplasia comprising an effective anti-neoplastic amount of actein and an effective anti-neoplastic amount of a statin, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A method for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject, comprising administering to the subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein.
A method for modulating a growth inhibitory effect of a statin on a carcinoma which comprises contacting the carcinoma with the statin and an effective amount of actein, which results in a synergistic effect of the statin on the carcinoma, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
A method for modulating Na+—K+-ATPase activity in a cell comprising contacting a cell that expresses Na+—K+-ATPase with actein and a statin, and optionally at least one additional chemopreventive or chemotherapeutic agent.
A method for treating, preventing or ameliorating liver cell neoplasia in a subject comprising administering to the subject an amount of actein effective to treat, prevent or ameliorate the liver cell neoplasia, and optionally an effective amount of at least one additional chemopreventive or chemotherapeutic agent.
Dependencies are inferred from the claim text.