Methods to treat alzheimer's disease or other disorders mediated by amyloid-beta accumulation in a subject
AssigneeWashington University in St. Louis
InventorsDavid Holtzman, David Piwnica-Worms, John R. Cirrito, Anne Fagan Niven
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Abstract
The invention provides methods of delaying the onset, slowing the progression, preventing, or treating Alzheimers disease in a subject. In particular, the invention provides methods of modulating transport of Aβ across the blood brain barrier of the subject.
Claims19
A method of delaying the onset, slowing the progression, preventing or treating Alzheimer's disease in a subject, the method comprising modulating P-glycoprotein mediated transport of Aβ across the blood brain barrier of the subject.
A method of modulating the concentration of Aβ in brain interstitial fluid of a subject, the method comprising modulating the P-glycoprotein mediated transport of Aβ across the blood brain barrier.
A method to modulate transport of Aβ from the brain interstitial fluid across the blood brain barrier in a subject, the method comprising modulating the activity of P-glycoprotein.
Dependencies are inferred from the claim text.