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US 2009/0264339 A1Published application
Heterocyclic Compounds
AssigneeTaiGen Biotechnology Co., Ltd.
InventorsChi-Feng Yen, Cheng-Kung Hu, Chang-Pin Huang, Ying-Huey Huang, Gholam Hossein Hakimelahi, Chi-Hsin Richard King
Life of this patent
Estimating the term…
Abstract
This invention relates to heterocyclic compounds of the formulas shown in the specification. It also relates to methods for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, and tissue injuries with one of the heterocyclic compounds.
Claims30
A compound of the following formula:
- wherein
- each Q and U is CH or N, provided that at least one of Q and U is N;
- each of X, Y, and Z, independently, is C1-5 alkylene or deleted;
- m is 0, 1, 2, 3, 4, or 5;
- n is 0, 1 or 2;
- p is 1 or 2;
- R1 is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, halo, CN, ORa, COORa, OC(O)Ra, C(O)Ra, C(O)NRaRb, or NRaRb;
- R2 is C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, or C1-C10 alkyl, optionally substituted with C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, or N(RcRd);
- R3, independently, is C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, halo, CN, ORe, COORe, OC(O)Re, C(O)Re, C(O)NReRf, or NReRf;
- or R3 is C1-5 alkylene bonded to two carbon atoms of the ring to which it is attached or C2-8 alkylene bonded to one carbon atom of the ring to which it is attached;
- and
- R4 is P(═O)(ORg)(ORi), P(═O)(NHRg)(ORi), P(═O)(NRg)(NRi), S(═O)2ORg, or S(═O)2Rg;
- in which each of Ra, Rb, Rc, Rd, Re, Rf, Rg and Ri, independently, is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, or —C(O)R, R being H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, or heteroaryl;
- or Ra and Rb are linked and together form C2-8 alkylene, Rc and Rd are linked and together form C2-8 alkylene, Re and Rf are linked and together form C2-8 alkylene, or Rg and Ri are linked and together form C1-5 alkylene.
11 more elements
A compound of the following formula:
- wherein
- U is CH or N,
- L is C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, or heteroaryl;
- each of Y and Z, independently, is C1-5 alkylene or deleted;
- m is 0, 1, 2, 3, 4, or 5;
- n is 0, 1 or 2;
- R1 is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, halo, CN, ORa, COORa, OC(O)Ra, C(O)Ra, C(O)NRaRb, or NRaRb;
- R2 is C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, or C1-C10 alkyl, optionally substituted with C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, or N(RcRd);
- R3 is C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, halo, CN, ORe, COORe, OC(O)Re, C(O)Re, C(O)NReRf, or NReRf;
- or R3 is C1-5 alkylene bonded to two carbon atoms of the ring to which it is attached or C2-8 alkylene bonded to one carbon atom of the ring to which it is attached;
- and
- R4 is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, ORg, COORg, C(O)Rg, or C(O)NRgRi;
- in which each of Ra, Rb, Rc, Rd, Re, Rf, Rg and Ri, independently, is H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, heteroaryl, or —C(O)R, R being H, C1-C10 alkyl, C3-C20 cycloalkyl, C1-C20 heterocycloalkyl, aryl, or heteroaryl;
- or Ra and Rb are linked and together form C2-8 alkylene, Rc and Rd are linked and together form C2-8 alkylene, Re and Rf are linked and together form C2-8 alkylene, or Rg and Ri are linked and together form C2-8 alkylene.
11 more elements
Dependencies are inferred from the claim text.