Polypeptides having a functional domain of interest and methods of identifying and using same
OwnerAndrew B. Sparks, Noah Hoffman +3inventors
InventorsAndrew B. Sparks, Noah Hoffman, Brian K. Kay, Dana M. Fowlkes, Stephen J. McConnell
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Abstract
Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.
Claims21
The method of identifying a polypeptide comprising a functional domain of interest comprising:
- (a) contacting a multivalent recognition unit complex with a plurality of polypeptides;
- and
- (b) identifying a polypeptide having a selective binding affinity for said recognition unit complex.
21-102. (canceled)
Dependencies are inferred from the claim text.