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US 2009/0264302 A1Published application
Methods, systems and computer program products for determining treatment response biomarkers
OwnerAchim Pluminventor
Life of this patent
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Abstract
The invention relates to methods for the identification of biomarkers suitable for determining patient treatment response as well as systems and computer program products of use in such methods.
Claims14
A method for determining CpG positions indicative of sensitivity or resistance to an agent comprising
- i. Determining the methylation status of a plurality of CpG positions within each of a plurality of biological samples
- ii. Exposing said biological samples to said agent
- iii. Determining the sensitivity or resistance of each of said biological samples to said agent
- iv. Classifying each of said plurality of biological samples into one of a plurality of classes according to said sensitivity or resistance
- v. Determining at least one or more CpG positions differentially methylated between two of said classes.
2 more elements
A system for determining methylation markers, comprising:
- (A) a computing device comprising:
- a dataset of a methylation profile of each of a plurality of biological samples;
- (B) means for providing a sensitivity or resistance profile for each of said biological samples;
- (C) means for generating in said computing device a classification of each of said plurality of biological samples into one of a plurality of classes according to said sensitivity or resistance;
- and
- (D) means for determining CpG positions differentially methylated between selected classes.
3 more elements
A distributed system for determining methylation markers, comprising:
- (A) a computing device, comprising:
- a first dataset of a methylation profile of each of a plurality of biological samples;
- (B) means for providing a sensitivity or resistance profile for each of said biological samples;
- (C) means for correlating each member of said second set of samples with the members of said first dataset;
- (D) means for generating in said computing device a classification of each of said plurality of biological samples of said first dataset into one of a plurality of classes according to said sensitivity or resistance;
- and
- (E) means for determining CpG positions differentially methylated between selected classes.
4 more elements
A computer program product for determining methylation markers comprising a computer usable storage medium having computer readable program code means embodied in the medium, the computer readable program code means comprising:
- (A) a computer readable dataset of a methylation profile of each of a plurality of biological samples;
- (B) computer readable program code means for providing a sensitivity or resistance profile for each of said biological samples;
- (C) computer readable program code means for generating in said computing device a classification of each of said plurality of biological samples into one of a plurality of classes according to said sensitivity or resistance;
- and
- (D) computer readable program code means for determining CpG positions differentially methylated between selected classes.
2 more elements
Dependencies are inferred from the claim text.