Phenotype-Genotype Relationship in Age-Related Macular Degeneration
AssigneeDuke University
InventorsR. Keith Shuler, JR., Eric A. Postel, Jennifer Caldwell, Silke Schmidt, Michael Hauser
Life of this patent
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Abstract
Age-Related Macular Degeneration (AMD) cases possessing the LOC387715 (rs10490924) variant have a higher risk of neovascular AMD. Individuals with AMD who are homozygous for both variants might be at greater risk for earlier onset of neovascular AMD. Determining the presence of this variant indicates which path the disease may take and which nutritional, supplement, or medicaments are appropriate.
Claims18
A method to assess risk of neovascular AMD in a patient comprising:
- assaying a sample of patient DNA or protein and determining whether the patient has a T allele at rs10490924;
- and
- identifying a patient with the T allele as being at higher risk of neovascular AMD than geographical atrophy.
A method to assess risk of neovascular AMD in a patient comprising:
- assaying a sample of patient DNA or protein and determining whether the patient has a T allele at rs10490924;
- and
- identifying a patient with the T allele as being at higher risk of neovascular AMD than a patient without the T allele.
A method to determine an appropriate regimen to prescribe to a patient for delaying onset of neovascular AMD in a patient comprising:
- assaying a sample of patient DNA or protein and determining whether the patient has two T alleles at rs10490924 in LOC687715 using a real-time polymerase chain reaction assay;
- identifying the patient as having an earlier predicted onset of neovascular AMD than a patient with one or no T allele at rs10490924 if the patient has two T alleles at rs10490924;
- and
- prescribing a medicament, supplement, or diet to the patient with two T alleles at rs10490924 to delay onset or to slow progression of neovascular AMD.
Dependencies are inferred from the claim text.