Tissue Engineering Devices and Methods for Luminal Organs
OwnerJoseph J. Hammer, Dhanuraj Shetty +4inventors
InventorsJoseph J. Hammer, Dhanuraj Shetty, Sridevi Dhanaraj, Ziwei Wang, Jeffrey C. Geesin, Daniel J. Keeley
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Abstract
Tissue engineering devices and methods are provided for the reconstruction, repair, augmentation, or replacement of a luminal organ or tissue structure involving the use of a biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ, the processing of autologous, allogeneic or xenogeneic tissue comprising multiple cell populations to obtain a minced tissue composition, the seeding of the matrix with the composition, and the implanting of the seeded polymer matrix into a patient.
Claims20
An organ reconstruction method comprising the steps of:
- providing a biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ;
- obtaining autologous, allogeneic or xenogeneic tissue comprising multiple cell populations;
- processing the tissue to obtain a minced tissue composition;
- seeding the matrix with the composition;
- and
- implanting into a patient the seeded polymer matrix.
An organ reconstruction method comprising the steps of:
- providing a biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ;
- obtaining autologous, allogeneic or xenogeneic tissue comprising multiple cell populations;
- processing the tissue to obtain a first minced tissue composition and a second minced tissue composition;
- seeding a first area of the matrix with the first minced tissue composition, and seeding a second area of the matrix with the second minced tissue composition;
- and
- implanting into a patient the seeded polymer matrix.
An organ reconstruction device comprising an implantable, biodegradable polymer matrix conforming to a portion of a laminarly arranged luminal organ, wherein said matrix is capable of being seeded with a processed tissue composition, which comprises minced autologous, allogeneic or xenogeneic tissue comprising multiple cell populations.
A reinforced organ reconstruction device comprising an implantable, biocompatible polymer mesh having a first surface and a second surface, further having a first biodegradable polymer matrix in contact with said first polymer mesh surface, and further having a second biodegradable polymer matrix in contact with said second polymer mesh surface, wherein said polymer matrix-mesh-matrix construct is conforming to a portion of a laminarly arranged luminal organ, and further wherein said first and second polymer matrices are capable of being seeded with a processed tissue composition, which comprises minced autologous, allogeneic or xenogeneic tissue comprising multiple cell populations.
Dependencies are inferred from the claim text.