Drug-eluting intravascular prostheses and methods of use
AssigneeMulti-Gene Vascular Systems LTD. ("MGVS")
InventorMoshe Flugelman
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Abstract
The present invention provides intravascular prostheses and methods of production and use. An implantable device for treating a vascular disease or disorder includes an intravascular prosthesis containing an inhibitor of smooth muscle cell proliferation and a growth factor. The device can be coated with a biodegradable drug-eluting polymer that is impregnated with the inhibitor of smooth muscle cell proliferation and the growth factor. The device is useful for treating or preventing a vascular disease or disorder such as restenosis, by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention.
Claims9
A method of treating a vascular disease or disorder by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention, the method comprising:
- a) placing a device outside or within a vessel of a subject in need thereof, wherein said device is coated with a biodegradable drug-eluting polymer that is impregnated with an inhibitor of smooth muscle cell proliferation and a growth factor for enhancing endothelial cell proliferation, wherein said inhibitor of smooth muscle cell proliferation is fibulin-5 polypeptide or a nucleic acid encoding fibulin-5 polypeptide, and wherein said growth factor for enhancing endothelial cell proliferation is VEGF polypeptide or a nucleic acid encoding VEGF polypeptide;
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- b) eluting said inhibitor and said growth factor from said device, thereby inhibiting smooth muscle cell proliferation and enhancing endothelial cell proliferation, and treating said vascular disease or disorder.
A method of treating a vascular disease or disorder by simultaneously inhibiting vessel blockage and enhancing recovery of the vessel wall following an intravascular intervention, the method comprising:
- placing a device outside or within a vessel of a subject in need thereof, wherein said device is coated with a substrate comprising endothelial cells that are genetically altered to express or over-express an inhibitor of smooth muscle cell proliferation and a growth factor for enhancing endothelial cell proliferation, wherein said inhibitor of smooth muscle cell proliferation is fibulin-5 polypeptide, and wherein said growth factor for enhancing endothelial cell proliferation is vascular endothelial growth factor (VEGF) polypeptide,
- thereby inhibiting smooth muscle cell proliferation and enhancing endothelial cell proliferation, and treating said vascular disease or disorder.
Dependencies are inferred from the claim text.