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AssigneeWarsaw Orthopedic, Inc.
InventorsChristopher M. Hobot, Phillip E. McDonald, Keith R. Hildebrand
Estimating the term…
Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
An implantable drug depot useful for reducing, preventing or treating pain in a patient in need of such treatment, the drug depot comprising a polyorthoester and a therapeutically effective amount of clonidine, the drug depot being administered at a site to reduce, prevent or treat pain, wherein the drug depot is capable of releasing clonidine at an amount between 0.005 and 1.0 mg per day for a period of 5 to 135 days at the site.
An implantable drug depot for reducing, preventing or treating pain in a patient in need of such treatment, the implantable drug depot comprising clonidine in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot, and a polyorthoester, wherein the drug depot is capable of releasing clonidine over a period of at least three days.
A method for treating acute pain, wherein said method comprises implanting a drug depot in an organism to reduce, prevent or treat pain, wherein said drug depot comprises clonidine in an amount from about 0.1 wt. % to about 30 wt. % of the drug depot, and a polyorthoester.
An implantable drug depot comprising:
Dependencies are inferred from the claim text.