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AssigneeStiefel Laboratories, Inc.
InventorsJerome Asius, Nicolas Riviere, Benedicte Asius
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The present invention relates to a crosslinked hyaluronic acid that can be obtained according to a process comprising: (a) activation of a hyaluronic acid, (b) reaction of the activated hyaluronic acid with an oligopeptide- or polypeptide-based crosslinking agent, in a reaction medium adjusted to a pH of from 8 to 12, so as to obtain a crosslinked hyaluronic acid, (c) adjustment of the pH of the reaction medium to a value ranging from 5 to 7, and (d) precipitation of the crosslinked hyaluronic acid from an organic solvent. It also relates to the above process, to a hydrogel obtained from the crosslinked hyaluronic acid and to the use of the crosslinked hyaluronic acid for the manufacture of implants that can be used in particular in plastic surgery.
Crosslinked hyaluronic acid that can be obtained according to a process comprising:
Sterilized hydrogel containing hyaluronic acid crosslinked with a crosslinking agent containing at least 50% by weight of oligopeptide or polypeptide, characterized in that it exhibits a variation in its elastic modulus of less than 30% after stoving at 93° C. for 1 hour.
Dependencies are inferred from the claim text.