Il-32b-targeted diagnosis and therapy
OwnerCharles Lininventor
Life of this patent
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Abstract
Methods for the diagnosis and treatment of IL-32β over-expressing cancers are provided. Also provided are methods for the treatment of wounds, hair loss and the promoting and/or restoration of hair growth utilized IL-32β antagonists. Finally, a sepsis model utilizing IL-32β is provided, as are methods for treating sepsis and inflammation using IL-32β antagonists.
Claims22
A method of diagnosing cancer comprising:
- (a) obtaining a cell sample from a subject suspected of having or at risk of developing cancer;
- (b) assessing IL-32β expression in one or more cells of said sample;
- and
- (c) comparing IL-32β expression to that observed in one or more normal cells;
- wherein elevated IL-32β expression in the cell or cells of step (b), as compared to the cell or cells of step (c), indicates that said subject has cancer.
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A method of treating cancer in a subject, said cancer being characterized by overexpression of IL-32β, comprising administering to said subject an antagonist of IL-32β function or expression.
14-16. (canceled)
19-20. (canceled)
A method or promoting or restoring hair growth in a subject comprising administering to a hair-producing cell of said subject an antagonist of IL-32β function or expression.
22-29. (canceled)
A method of treating sepsis in a subject comprising administering to said subject an IL-32β-specific antagonist.
A method promoting wound healing in a subject comprising administering to said subject an antagonist of IL-32β function or expression.
32-40. (canceled)
Dependencies are inferred from the claim text.