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US 2009/0263374 A1Published application
Method of preventing and treating brain infarction
AssigneeKowa Company, Ltd.
InventorsKoji Abe, Junichi Kawagoe
Life of this patent
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AssigneeKowa Company, Ltd.
InventorsKoji Abe, Junichi Kawagoe
Estimating the term…
The present invention is intended to clarify the relationship between PAR-2 and cerebral infarction and thereby provide an efficient method of preventing and treating cerebral infarction, as well as a pharmaceutical composition therefore. Namely, the present invention relates to a method of preventing and treating cerebral infarction by activating PAR-2 and/or promoting expression of PAR-2 gene. The present invention further relates to a pharmaceutical composition for preventing and treating cerebral infarction, comprising one, or two or more of the active ingredients selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter; as well as a pharmaceutically acceptable carrier. It further relates to a method of screening an active ingredient for preventing and treating cerebral infarction using as an indicator the PAR-2 activation promoted by a test substance.
A method of preventing and treating cerebral infarction by activating PAR-2 and/or promoting the expression of PAR-2 gene.
A method of preventing and treating cerebral infarction, comprising administrating one, or two or more of active ingredients in an effective amount selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter to a patient suffering from cerebral infraction or at risk of having it.
A pharmaceutical composition for preventing and treating cerebral infarction, comprising one, or two or more of active ingredients selected from the group consisting of a PAR-2 activator and/or a PAR-2 gene expression promoter;
A use of a PAR-2 activator and/or a PAR-2 gene expression promoter for manufacture of medicament for preventing and treating cerebral infarction.
A method of screening an active ingredient for preventing and treating cerebral infarction using as an indicator the PAR-2 activation promoted by a test substance.
A method of screening active ingredients for preventing and treating cerebral infarction, comprising the screening of the test substance with the function of activating PAR-2 or promoting expression of PAR-2 gene by contacting the test substances with a cell expressing PAR-2 to determine expression or activity of PAR-2.
Dependencies are inferred from the claim text.