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US 2009/0263364 A1Published application
Method and constructs for delivering double stranded rna to pest organisms
AssigneeDevgen NV
InventorsThierry Andre Olivier Eddy Bogaert, Richard Zwaal, Geert Plaetinck, Jan Octaaf De Kerpel, Titus Jan Kaletta
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Abstract
The present invention relates in generally to RNAi and its use in gene silencing. In particular, the present invention relates to methods and constructs for delivering double stranded RNA (dsRNA) to pest organisms.
Claims43
An RNA delivery molecule consisting of a polypeptide sequence comprising
- i) at least one RNA-binding domain,
- ii) at least one targeting polypeptide able to bind to a cellular endocytosis and/or transcytosis receptor molecule, and
- iii) optionally at least one peptide linker for linking the RNA binding domain (i) to the targeting polypeptide (ii).
A chimeric RNAi molecule comprising
- at least one nucleotide sequence recognized by an RNA-binding protein or RNA-binding domain, for instance as represented in any of SEQ ID NOs 15 to 40, or an RNA secondary structure as represented in FIG. 41 or 42, and,
- at least one nucleotide sequence corresponding to a target nucleotide sequence of a target gene of a pest species.
-46. (canceled)
Dependencies are inferred from the claim text.