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AssigneeAgensys, Inc.
InventorsARTHUR B. RAITANO, AYA JAKOBOVITS, PIA M. CHALLITA-EID, WANGMAO GE, JUAN J. PEREZ-VILLAR, STEVEN B. KANNER
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A novel gene 254P1D6B and its encoded protein, and variants thereof, are described wherein 254P1D6B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 254P1D6B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 254P1D6B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 254P1D6B can be used in active or passive immunization.
An antibody or fragment thereof that specifically binds to a protein with an amino acid sequence that is 90% homologous to (SEQ ID NOS:
A method of inhibiting growth of cancer cells that express a protein with an amino acid sequence that is 90% homologous to SEQ ID NOS:
A method of generating a mammalian immune response directed to a protein comprising:
A method for detecting the presence of a protein comprises an amino acid sequence that is 90% homologous to SEQ ID NOS:
Dependencies are inferred from the claim text.