Diagnosis of carcinoma using RAIG1 polypeptides

A method of screening for and/or diagnosis of carcinoma in a subject, and/or monitoring the effectiveness of carcinoma therapy, which comprises the step of detecting and/or quantifying in a biological sample obtained from said subject:

• (i) a RAIG1 polypeptide which:
• a) comprises or consists of the amino acid sequence of SEQ ID NO:1;
• b) is a derivative having one or more amino acid substitutions, modifications, deletions or insertions relative to the amino acid sequence of SEQ ID NO:
• 1 which retains the activity of RAIG1;
• or
• c) is a fragment of a polypeptide having the amino acid sequence of SEQ ID NO:
• 1, which is at least ten amino acids long and has at least 70% homology over the length of the fragment;
• or
• (ii) a nucleic acid molecule which:
• d) comprises or consists of the DNA sequence of SEQ ID NO:
• 2 or its RNA equivalent;
• e) has a sequence which is complementary to the sequences of d);
• f) has a sequence which codes for a polypeptide as defined in any of a) to c) above;
• g) has a sequence which shows substantial identity with any of those of d), e) and f);
• or
• h) is a fragment of d), e), f) or g), which is at least 10 nucleotides in length.