Methods for treating juvenile idiopathic arthritis
AssigneeAbbVie Biotechnology Ltd.
InventorsJohn R. Medich, Susan K. Paulson, Peter A. Noertersheuser
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Abstract
The invention provides methods and compositions for the treatment of juvenile idiopathic arthritis (JIA) where a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat JIA. In particular, the invention is directed to methods and compositions relating to a fixed dosing regimen for treating JIA with a TNFα inhibitor.
Claims42
A method for treating juvenile idiopathic arthritis (JIA) in a subject comprising administering a TNFα inhibitor to the subject, wherein the TNFα inhibitor is administered to the subject according to a fixed dosing regimen.
8-10. (canceled)
A method for treating juvenile idiopathic arthritis (JIA) in a subject comprising subcutaneously administering a human TNFα antibody, or antigen-binding portion thereof, to the subject, wherein the TNFα inhibitor is administered to the subject according to a fixed dosing regimen.
A method for treating juvenile idiopathic arthritis (JIA) in a subject comprising administering a TNFα inhibitor to the subject, wherein a mean steady-state trough serum of the TNFα inhibitor is about 6 to 7 μg/mL.
A method for treating juvenile idiopathic arthritis (JIA) in a subject comprising administering a TNFα inhibitor to the subject, wherein a mean steady-state trough serum of the TNFα inhibitor is about 8 to 9 μg/mL.
A method for treating juvenile idiopathic arthritis (JIA) in a subject comprising administering a TNFα inhibitor to the subject, wherein a mean steady-state trough serum of the TNFα inhibitor is about 10-11 μg/mL.
An article of manufacture comprising a TNFα inhibitor and a label or package insert, wherein the label or package insert indicates that the TNFα inhibitor may be used to treat JIA by administering a fixed dose amount to a subject in need thereof.
Dependencies are inferred from the claim text.